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AB313007

Alexa Fluor® 568 Anti-alpha smooth muscle Actin 抗体 [SP171]

Alexa Fluor® 568 Anti-alpha smooth muscle Actin antibody [SP171]

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Rabbit Recombinant Monoclonal alpha smooth muscle Actin antibody - conjugated to Alexa Fluor® 568.

別名を表示する

ACTSA, ACTVS, GIG46, ACTA2, Alpha-actin-2, Cell growth-inhibiting gene 46 protein

関連する標識済み抗体及び組成の異なる製品 (9)

  • Unconjugated

    Anti-alpha smooth muscle Actin antibody [SP171]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-alpha smooth muscle Actin antibody [SP171]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-alpha smooth muscle Actin antibody [SP171]

  • 660 APC

    APC Anti-alpha smooth muscle Actin antibody [SP171]

  • 578 PE

    PE Anti-alpha smooth muscle Actin antibody [SP171]

  • Carrier free

    Anti-alpha smooth muscle Actin antibody [SP171] - BSA and Azide free

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-alpha smooth muscle Actin antibody [SP171]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-alpha smooth muscle Actin antibody [SP171]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-alpha smooth muscle Actin antibody [SP171]

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

SP171

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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下記製品にもご興味をお持ちいただけるかもしれません:

AB240678

Human alpha SMA ELISA Kit

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こちらの製品も推奨する理由

この製品は、同様の実験や関連する研究で広く使用されていることから推奨させていただいております。

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製品の詳細

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Alpha smooth muscle actin (α-SMA) also known as ACTA2 is an actin isoform with a specific role in the contractile function of smooth muscle cells. The molecular weight of α-SMA is approximately 42 kDa. This protein is expressed widely in vascular smooth muscle cells the peritoneal lining and myofibroblasts. It often serves as a marker for these cell types. The expression of α-SMA is critical for the mechanical attributes of cells contributing to the rigidity and contractility of tissues where it is present.
Biological function summary

Alpha smooth muscle actin aids in maintaining the structural integrity of tissues by forming part of the actin cytoskeleton an important element in cellular support. It exists in high concentration in stress fibers contributing to cellular movements and shape maintenance. These actions are essential in various dynamic cellular processes such as cell migration and adhesion. Alpha smooth muscle actin does not typically form complexes but it associates with other components of the actin cytoskeleton to ensure cell stability and function.

Pathways

Alpha smooth muscle actin functions significantly within the TGF-beta signaling pathway which influences cell proliferation differentiation and apoptosis. It interacts closely with proteins such as myosin to facilitate cellular contractility and motility. Additionally α-SMA plays a part in the RhoA/Rho kinase (ROCK) pathway connecting with regulators of actin filament organization. These pathways are essential for modulation of smooth muscle contraction and actin filament assembly contributing to vascular development and wound healing.

Alpha smooth muscle actin is importantly involved in fibrotic diseases and vascular diseases like arteriosclerosis. Increased expression of α-SMA is often observed in fibrotic tissues contributing to pathogenesis due to excessive extracellular matrix deposition. In the context of vascular disorders overexpression of α-SMA can lead to abnormal vascular remodeling often seen in diseases like hypertension. Interactions with proteins such as fibronectin and collagens facilitate these pathological changes highlighting the importance of α-SMA in disease development.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
See full target information ACTA2
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