Alexa Fluor® 568 Anti-AICDA 抗体 [EPR23436-45] - ChIP Grade
Alexa Fluor® 568 Anti-AICDA antibody [EPR23436-45] - ChIP Grade
- RabMAb
- Recombinant
- 詳細を見る
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Rabbit Recombinant Monoclonal AICDA antibody - conjugated to Alexa Fluor® 568.
別名を表示する
AID, AICDA, Single-stranded DNA cytosine deaminase, Activation-induced cytidine deaminase, Cytidine aminohydrolase
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Anti-AICDA antibody [EPR23436-45] - ChIP Grade - BSA and Azide free
製品の詳細
Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.
出荷温度及び保存条件
製品の状態
精製方法
バッファー組成
出荷温度
短期保存期間
短期保存温度
長期保存温度
分注に関する情報
保管に関する情報
補足情報
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
AICDA plays an important role in the adaptive immune system by facilitating the diversification of antibodies. It does not appear to function as part of a larger protein complex but operates independently to induce mutations in variable regions of immunoglobulin genes. This activity enables B cells to produce antibodies with higher affinity and different isotypes important for an effective immune defense system. AICDA’s function ensures the generation of diverse antibody repertoires allowing the immune system to effectively target a wide range of pathogens.
Pathways
AICDA is integral to the immunoglobulin gene diversification pathway. It initiates somatic hypermutation and class switch recombination by deaminating cytosine residues in the DNA of immunoglobulin genes. This action relates AICDA to other proteins involved in DNA repair and error-prone replication such as uracil-DNA glycosylase (UNG) and the mismatch repair proteins like MSH2 and MSH6. AICDA's deamination activity triggers the recruitment of these proteins to introduce mutations and remove uracil residues facilitating the generation of antibody diversity.
製品プロトコール
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ターゲットの情報
Abcam product promise
関連製品
Alternative Version
Primary Antibodies
AB269457
Anti-AICDA antibody [EPR23436-45] - ChIP Grade - BSA and Azide free
primary-antibodies
aicda-antibody-epr23436-45-chip-grade-bsa-and-azide-free-ab269457
5
(1 reviews)
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