AB312059

Alexa Fluor® 555 Anti-RABL3 抗体 [EPR16709] - C-terminal

Alexa Fluor® 555 Anti-RABL3 antibody [EPR16709] - C-terminal

RabMAb
Recombinant
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Rabbit Recombinant Monoclonal RABL3 antibody - conjugated to Alexa Fluor® 555. Suitable for Target Binding Affinity, Antibody Labelling, Flow Cyt (Intra), ICC/IF, IHC-P and reacts with Human, Rat samples.

別名を表示する

Rab-like protein 3, RABL3

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR16709

アイソタイプ

IgG

標識

Alexa Fluor® 555

励起波長/蛍光波長

Ex: 555nm, Em: 565nm

キャリアフリー

交差種

Human, Rat

アプリケーション

IHC-P, Flow Cyt (Intra), Target Binding Affinity, Antibody Labelling, ICC/IF

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "TargetBindingAffinity" : {"fullname" : "Target Binding Affinity", "shortname":"Target Binding Affinity"}, "AntibodyLabelling" : {"fullname" : "Antibody Labelling", "shortname":"Antibody Labelling"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "TargetBindingAffinity-species-checked": "guaranteed", "TargetBindingAffinity-species-dilution-info": "", "TargetBindingAffinity-species-notes": "", "AntibodyLabelling-species-checked": "guaranteed", "AntibodyLabelling-species-dilution-info": "", "AntibodyLabelling-species-notes": "", "FlowCytIntra-species-checked": "guaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "TargetBindingAffinity-species-checked": "guaranteed", "TargetBindingAffinity-species-dilution-info": "", "TargetBindingAffinity-species-notes": "", "AntibodyLabelling-species-checked": "guaranteed", "AntibodyLabelling-species-dilution-info": "", "AntibodyLabelling-species-notes": "", "FlowCytIntra-species-checked": "guaranteed", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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製品の詳細

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle|Store in the dark

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

RABL3 also known as Rab-like protein 3 is a member of the Rab-like small GTPase family. It has a molecular mass of approximately 28 kDa. RABL3 plays a central role in cellular trafficking and transport by acting as a molecular switch cycling between an active GTP-bound state and an inactive GDP-bound state. Expression of RABL3 is widespread across various tissues although its exact expression pattern may vary depending on the cell type and physiological condition.

Biological function summary

RABL3 functions in the regulation of intracellular signaling pathways. It associates with other molecular partners to influence the dynamics of cargo transport through vesicles. While it is not specifically identified as part of a larger complex its interactions with other small GTPases suggest a collaborative role in vesicle docking and fusion processes. RABL3's function impacts cell communication and signal transduction vital processes in maintaining cellular homeostasis and response to environmental signals.

Pathways

RABL3 engages in the RAS signaling pathway where it may regulate downstream effects of RAS activation. In particular it can interact with proteins like RAB6 and RABL2 which share similar roles in vesicular trafficking and transport. The RAS signaling pathway's influence in growth and metabolism provides insight into RABL3's potential to modulate signal transduction efficiency and cellular response mechanisms.

Defects in RABL3 are associated with certain forms of cancer and neurodegenerative disorders. Its involvement is particularly noted in its connection to the KRAS protein which is significantly implicated in oncogenic transformations. Alterations in RABL3 expression or function may disrupt normal cellular signaling and transport contributing to disease progression. Understanding these interactions can help target therapeutic strategies for conditions related to these dysregulated pathways.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Required for KRAS signaling regulation and modulation of cell proliferation (PubMed : 31406347). Regulator of KRAS prenylation, and probably prenylation of other small GTPases (PubMed : 31406347). Required for lymphocyte development and function (By similarity). Not required for myeloid cell development (By similarity).

See full target information Rab-like protein 3

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Alexa Fluor® 555 Anti-RABL3 抗体 [EPR16709] - C-terminal

Alexa Fluor® 555 Anti-RABL3 antibody [EPR16709] - C-terminal

関連する標識済み抗体及び組成の異なる製品 (9)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

標識

励起波長/蛍光波長

キャリアフリー

交差種

アプリケーション

免疫原

組合せ製品

Reagents, Controls & Accessories

Primary Antibodies

Assay Kits

Primary Antibodies

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

Abcam product promise