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AB307625

Alexa Fluor® 555 Anti-mGluR1a 抗体 [EPR24160-173]

Alexa Fluor® 555 Anti-mGluR1a antibody [EPR24160-173]

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Rabbit Recombinant Monoclonal GRM1 antibody - conjugated to Alexa Fluor® 555. Suitable for IHC-P and reacts with Rat, Mouse samples.

別名を表示する

Gprc1a, Mglur1, Grm1, Metabotropic glutamate receptor 1, mGluR1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 555 Anti-mGluR1a antibody [EPR24160-173] (AB307625)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 555 Anti-mGluR1a antibody [EPR24160-173] (AB307625)

Immunohistochemical analysis of paraffin-embedded Mouse lung tissue labeling mGluR1a with ab307625 at 1/50 (10.0 μg/ml). Negative control : no staining on mouse lung. The section was incubated with ab307625 at 4°C overnight (shown in red). Nuclear DNA was labelled with DAPI (shown in blue). The section was then mounted using Fluoromount®. Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8). Heat mediated antigen retrieval was performed using ab93684 (Tris/EDTA buffer, pH 9.0).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 555 Anti-mGluR1a antibody [EPR24160-173] (AB307625)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 555 Anti-mGluR1a antibody [EPR24160-173] (AB307625)

Immunohistochemical analysis of paraffin-embedded Rat cerebellum tissue labeling mGluR1a with ab307625 at 1/50 (10.0 μg/ml). Positive staining on rat cerebellum. The section was incubated with ab307625 at 4°C overnight (shown in red). Nuclear DNA was labelled with DAPI (shown in blue). The section was then mounted using Fluoromount®. Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8). Heat mediated antigen retrieval was performed using ab93684 (Tris/EDTA buffer, pH 9.0).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 555 Anti-mGluR1a antibody [EPR24160-173] (AB307625)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 555 Anti-mGluR1a antibody [EPR24160-173] (AB307625)

Immunohistochemical analysis of paraffin-embedded Mouse cerebellum tissue labeling mGluR1a with ab307625 at 1/50 (10.0 μg/ml). Positive staining on mouse cerebellum. The section was incubated with ab307625 at 4°C overnight (shown in red). Nuclear DNA was labelled with DAPI (shown in blue). The section was then mounted using Fluoromount®. Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8). Heat mediated antigen retrieval was performed using ab93684 (Tris/EDTA buffer, pH 9.0).

関連する標識済み抗体及び組成の異なる製品 (3)

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR24160-173

アイソタイプ

IgG

標識

Alexa Fluor® 555

励起波長/蛍光波長

Ex: 555nm, Em: 565nm

キャリアフリー

No

交差種

Rat, Mouse, Mouse, Rat

アプリケーション

IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50", "IHCP-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50", "IHCP-species-notes": "<p></p>" } } }
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製品の詳細

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

MGluR1a also known as metabotropic glutamate receptor 1a is a G-protein coupled receptor with a mass of approximately 153 kDa. This receptor binds glutamate an excitatory neurotransmitter and initiates intracellular signaling by activating G-proteins. It is expressed in various regions of the brain such as the cerebellum hippocampus and olfactory bulb. The receptor is involved in modulating several synaptic processes by influencing the release of neurotransmitters.
Biological function summary

Glutamate receptor mGluR1a plays a significant role in neuroplasticity and synaptic transmission. It does not act alone but is part of a larger group of metabotropic glutamate receptors. These receptors participate in both excitatory and inhibitory signaling pathways affecting signal regulation and neuron connectivity. mGluR1a contributes to learning and memory processes through its ability to modulate synaptic strength.

Pathways

MGluR1a is an important component in the phosphatidylinositol signaling system and the glutamatergic synapse pathway. Both pathways are related to calcium ion homeostasis and protein trafficking in neurons. Among the related proteins Homer and Shank play a role in the mGluR1a signaling complex and aid in its function within these pathways affecting synaptic structure and plasticity.

MGluR1a is associated with several neuropathological conditions. Alterations in its function or expression can contribute to the development of neurodegenerative diseases like Alzheimer’s disease and psychiatric disorders such as schizophrenia. The receptor interacts with proteins like amyloid precursor protein (APP) and SynGAP which play roles in the etiology and progression of these conditions. Dysregulation of mGluR1a signaling may affect neuronal death and lead to cognitive defects seen in these diseases.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity). May function in the light response in the retina (PubMed : 26427409). Induces GRID1 and GRID2 cation-channel activation via GNAQ-PLC-PKC pathway in dopaminergic neurons and cerebellar Purkinje cell, respectively (PubMed : 24357660, PubMed : 27276689, PubMed : 28696429).
See full target information Grm1
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組合せ製品

Biochemicals

AB120007

(S)-3,5-DHPG, group I mGlu agonist

Functional Studies - (S)-3,5-DHPG, group I mGlu agonist (AB120007)

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Abcam product promise

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