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AB311917

Alexa Fluor® 555 Anti-Amylin/DAP 抗体 [EPR22556-138]

Alexa Fluor® 555 Anti-Amylin/DAP antibody [EPR22556-138]

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Rabbit Recombinant Monoclonal Amylin/DAP antibody - conjugated to Alexa Fluor® 555.

別名を表示する

Islet amyloid polypeptide, IAPP, Amylin, Diabetes-associated peptide, DAP, Iapp

関連する標識済み抗体及び組成の異なる製品 (10)

  • Unconjugated

    Anti-Amylin/DAP antibody [EPR22556-138]

  • 578 PE

    PE Anti-Amylin/DAP antibody [EPR22556-138]

  • HRP

    HRP Anti-Amylin/DAP antibody [EPR22556-138]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Amylin/DAP antibody [EPR22556-138]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Amylin/DAP antibody [EPR22556-138]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Amylin/DAP antibody [EPR22556-138]

  • 603 Alexa Fluor® 568

    Alexa Fluor® 568 Anti-Amylin/DAP antibody [EPR22556-138]

  • 660 APC

    APC Anti-Amylin/DAP antibody [EPR22556-138]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-Amylin/DAP antibody [EPR22556-138]

  • Carrier free

    Anti-Amylin/DAP antibody [EPR22556-138] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR22556-138

アイソタイプ

IgG

標識

Alexa Fluor® 555

励起波長/蛍光波長

Ex: 555nm, Em: 565nm

キャリアフリー

No

アプリケーション

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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製品の詳細

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Amylin also known as Islet Amyloid Polypeptide (IAPP) is a peptide hormone mainly produced and co-secreted with insulin by pancreatic beta cells. This peptide has a molecular mass of approximately 3.9 kDa. Amylin is highly expressed in the pancreas with some expression in the gastrointestinal tract and the central nervous system. In images DAP typically refers to 4'6-diamidino-2-phenylindole which isn't directly related to amylin but this clarification can avoid confusion in laboratory discussions.
Biological function summary

Amylin peptide regulates blood glucose levels by slowing gastric emptying and promoting satiety. It acts as part of a complex with calcitonin receptor and a receptor activity-modifying protein to mediate its effects efficiently. Amylin influences the central nervous system by affecting appetite and has roles in bone metabolism through interactions with receptors related to alkaline phosphatase 138.

Pathways

Amylin functions in the glucose homeostasis and energy regulation pathways. It closely works with insulin impacting how the body manages postprandial glucose spikes. The peptide also interacts with cAMP signaling which is part of the same network that involves proteins like glucagon-like peptide-1 (GLP-1) which harmonizes action between different metabolic regulatory components.

Amylin accumulates in the form of amyloid deposits in type 2 diabetes contributing to the degeneration of beta cells. The presence of amylin aggregates connects with insulin in this pathology aggravating disease progression. Moreover the peptide plays a part in Alzheimer's disease where its amyloidogenic properties may have overlapping mechanisms with amyloid beta deposits impacting neurodegeneration through similar receptor pathways.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (By similarity). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes. Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity).
See full target information Iapp
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB255329

Anti-Amylin/DAP antibody [EPR22556-138] - BSA and Azide free

primary-antibodies

amylin-dap-antibody-epr22556-138-bsa-and-azide-free-ab255329

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