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リコンビナントRabMAb

Alexa Fluor® 488 Anti-FOXP1 抗体 [SP133] (ab303573)

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Flow Cytometry (Intracellular) - Alexa Fluor® 488 Anti-FOXP1 antibody [SP133] (ab303573)
  • Alexa Fluor® 488 Anti-FOXP1 antibody [SP133] (ab303573)
  • Alexa Fluor® 488 Anti-FOXP1 antibody [SP133] (AB303573)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Alexa Fluor® 488 Rabbit monoclonal [SP133] to FOXP1 - C-terminal
  • Suitable for: Flow Cyt (Intra)
  • Reacts with: Human
  • Conjugation: Alexa Fluor® 488. Ex: 495nm, Em: 519nm

Conjugates logo Related conjugates and formulations

Carrier Free Unconjugated

製品の概要

  • 製品名

    Alexa Fluor® 488 Anti-FOXP1 antibody [SP133]
    FOXP1 一次抗体 製品一覧

  • 製品の詳細

    Alexa Fluor® 488 Rabbit monoclonal [SP133] to FOXP1 - C-terminal

  • 由来種

    Rabbit

  • 標識

    Alexa Fluor® 488. Ex: 495nm, Em: 519nm

  • アプリケーション

    適用あり: Flow Cyt (Intra)more details

  • 種交差性

    交差種: Human

  • 免疫原

    Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

  • ポジティブ･コントロール

    • Flow Cyt (Intra): Human PBMCs.

  • 特記事項

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

    Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

製品の特性

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab303573の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
Flow Cyt (Intra)
1/2500.
特記事項
Flow Cyt (Intra)
1/2500.

ターゲット情報

  • 機能

    Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development.

  • 関連疾患

    Note=A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.
    Defects in FOXP1 are the cause of mental retardation with language impairment and autistic features (MRLIAF) [MIM:613670]. It is a developmental disorder characterized by mild to moderate mental retardation, language impairment, and autistic features. Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities, including irritability, hyperactivity, aggression, and stereotypical rigid behaviors.

  • 配列類似性

    Contains 1 C2H2-type zinc finger.
    Contains 1 fork-head DNA-binding domain.

  • ドメイン

    The leucine-zipper is required for dimerization and transcriptional repression.

  • 細胞内局在

    Nucleus.
  • Information by UniProt

  • 参照データベース

    • 別名

      • 12CC4 antibody
      • FLJ23741 antibody
      • Fork head related protein like B antibody
      • Forkhead box P1 antibody
      • Forkhead box protein P1 antibody
      • FOX P1 antibody
      • FOXP 1 antibody
      • foxp1 antibody
      • FOXP1_HUMAN antibody
      • Glutamine rich factor 1 antibody
      • hFKH1B antibody
      • HSPC215 antibody
      • MGC12942 antibody
      • MGC88572 antibody
      • MGC99551 antibody
      • QRF 1 antibody
      • QRF1 antibody
      see all

    画像

    • Flow Cytometry (Intracellular) - Alexa Fluor® 488 Anti-FOXP1 antibody [SP133] (ab303573)
      Flow Cytometry (Intracellular) - Alexa Fluor® 488 Anti-FOXP1 antibody [SP133] (ab303573)

      Flow cytometry staining of human peripheral blood mononuclear cells (PBMCs) with ab303573 (right) or Rabbit IgG (monoclonal) Alexa Fluor®488 (ab199091) isotype (left). Cells were fixed and permeabilized with BD Cytofix/Cytoperm™ for 20 min. PBMCs were incubated for 30 min on ice in 1x PBS containing 10 µg/ml human IgG and 10% normal goat serum to block FC receptors and non-specific protein-protein interaction followed by the antibody (ab303573) or Rabbit IgG (monoclonal) Alexa Fluor®488 (ab199091) isotype (100 µl at 0.2 µg/ml (1/2500)) for 30 min on ice. The cells were simultaneously stained with CD4.

      Acquisition of >30000 events were collected using a 50 mW Blue laser (488 nm) and 525/40 bandpass filter.

      Events were gated on live lymphocytes.

    • Alexa Fluor® 488 Anti-FOXP1 antibody [SP133] (ab303573)
      Alexa Fluor® 488 Anti-FOXP1 antibody [SP133] (ab303573)
    • Alexa Fluor® 488 Anti-FOXP1 antibody [SP133] (AB303573)
      Alexa Fluor® 488 Anti-FOXP1 antibody [SP133] (AB303573)

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab303573 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab303573 は論文での使用が確認できていません。

    レビューと Q&A

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com