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AB49947

Anti-Aldosterone 3 抗体

Anti-Aldosterone 3 antibody

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Rabbit Polyclonal Aldosterone 3 antibody. Suitable for RIA and reacts with Chemical samples. Immunogen corresponding to Chemical / Small Molecule corresponding to Aldosterone 3.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

アプリケーション

RIA

applications

特異性

Cross Reactivity: 11- Deoxycorticosterone 1.1% Estradiol < 0.001% 11- Deoxycortisol < 0.001% Androsterone < 0.001% 21- Deoxycortisol < 0.001% Estriol < 0.001% Cortisone < 0.001% Estrone < 0.001% Testosterone < 0.01% Dihydrotesterone < 0.001%

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "RIA" : {"fullname" : "Radioimmunoassay", "shortname":"RIA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "RIA-species-checked": "guaranteed", "RIA-species-dilution-info": "", "RIA-species-notes": "<p></p>" } } }

出荷温度及び保存条件

製品の状態
Liquid
精製度
Whole antiserum
バッファー組成
Constituents: Whole serum
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Aldosterone 3 known also as CYP11B2 is an enzyme involved in the biosynthesis of aldosterone. It belongs to the cytochrome P450 family and exhibits a mass of approximately 58 kDa. The enzyme is highly expressed in the zona glomerulosa of the adrenal cortex where it facilitates the conversion of corticosterone to aldosterone by catalytic hydroxylation processes. The key role of Aldosterone 3 in this conversion highlights its important enzymatic function in steroid hormone production.
Biological function summary

The process of converting corticosterone into aldosterone by CYP11B2 contributes significantly to the regulation of blood pressure and fluid balance. This enzyme operates within a complex of electron transfer proteins ensuring the supply of electrons for effective catalysis. It partners with adrenodoxin and adrenodoxin reductase to perform its functions. This cooperation allows for the precise control of aldosterone release into the bloodstream affecting the balance of sodium and potassium.

Pathways

Aldosterone 3 plays an important role in the renin-angiotensin-aldosterone system (RAAS) which is central to cardiovascular regulation and fluid homeostasis. Within this pathway CYP11B2 activity links closely with angiotensin II a peptide that stimulates its expression and action. RAAS integrates the function of other proteins such as aldosterone synthase connecting several feedback mechanisms that control blood pressure.

Mutations or dysregulation in CYP11B2 are linked to conditions like primary aldosteronism and hypertension. Alterations in Aldosterone 3 activity lead to imbalances in aldosterone secretion which can cause high blood pressure or contribute to cardiovascular diseases. The enzyme’s relationship with angiotensin-converting enzyme (ACE) through RAAS adds complexity to how it impacts disease processes bridging connections between genetic molecular and systemic levels in the development of these health conditions.

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