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AB227231

Anti-AKR7A3 抗体

Anti-AKR7A3 antibody

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(3 Publications)

Rabbit Polyclonal AKR7A3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human AKR7A3.

別名を表示する

AFAR2, AKR7A3, Aldo-keto reductase family 7 member A3, AFB1 aldehyde reductase 2, Aflatoxin B1 aldehyde reductase member 3, AFB1-AR 2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AKR7A3 antibody (AB227231)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AKR7A3 antibody (AB227231)

Paraffin-embedded CL1-5 xenograft tissue stained for AKR7A3 using ab227231 at 1/100 dilution in immunohistochemical analysis.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Human AKR7A3. The exact immunogen used to generate this antibody is proprietary information.

O95154

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組合せ製品

Primary Antibodies

AB32503

Anti-Bax antibody [E63]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bax antibody [E63] (AB32503)

  • 4
  • 12
Primary Antibodies

AB109520

Anti-p21 antibody [EPR362]

RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Western blot - Anti-p21 antibody [EPR362] (AB109520)

  • 4
  • 16
Assay Kits

AB102536

BCA Protein Assay Kit

Functional Studies - BCA Protein Assay Kit (AB102536)

  • 0
  • 0
Primary Antibodies

AB184675

Alexa Fluor® 488 Anti-alpha smooth muscle Actin antibody [1A4]

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 488 Anti-alpha smooth muscle Actin antibody [1A4] (AB184675)

  • 5
  • 8
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

AKR7A3 also known as aflatoxin aldehyde reductase is an enzyme that functions mechanically to reduce aldehyde substrates to alcohols. This protein weighs approximately 36 kDa and is expressed widely in human tissues with higher levels in the liver and kidneys. AKR7A3 belongs to the aldo-keto reductase superfamily which is involved in detoxifying reactive carbonyl species playing an important role in protecting cells from oxidative stress.
Biological function summary

The detoxifying enzyme AKR7A3 significantly contributes to cellular defense mechanisms by converting toxic aldehydes such as those from lipid peroxidation into less harmful alcohols. It does not commonly form part of any protein complex but interacts indirectly with other detoxification enzymes to maintain cellular redox balance. Its activity supports cell survival under conditions of oxidative stress by mitigating the damaging effects of reactive aldehyde intermediates.

Pathways

AKR7A3 is instrumental in the metabolism of xenobiotics and the inflammatory response pathways. It plays a role in pathways alongside enzymes like glutathione S-transferase contributing to the detoxification of electrophiles and reactive aldehydes. This protective action reduces cellular oxidative stress functioning in tandem with enzymes involved in glutathione metabolism to safeguard cellular components from damage.

AKR7A3 has associations with liver pathologies including hepatocellular carcinoma and metabolic disorders involving oxidative stress. It shares a connection with proteins like Nrf2 which regulates the expression of antioxidant proteins and contributes to the cellular response against oxidative damage. Altered expression or function of AKR7A3 can impact the detoxification processes potentially leading to increased susceptibility to liver disease and cancer development.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Catalyzes the NADPH-dependent reduction of various carbonyl-containing compounds, including aldehydes, ketones, and toxic products from cellular metabolism or environmental exposure. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates, thus preventing the formation of protein adducts that contribute to AFB1-induced toxicity.
See full target information AKR7A3
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Biomedicines 13: PubMed41007649

2025

Inhibiting Suppresses Cell Proliferation by Upregulating the Apoptotic Pathway in Multiple Myeloma.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan Tao,Lihua Yuan,Yuntian Ding,Rongli Xie,Fangjie Liu,Zhongming Zhang,Xiaojun Xu,Xiaobo Wang

Frontiers in pharmacology 16:1534118 PubMed40365308

2025

Triptolide alleviates psoriasis through inhibiting the Wnt5a/β-Catenin signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Eryang Chen,Lei Wang,Qu Wang,Yan Cai,Yaning Dou,Hongyan Qu,Junyi Zhu,Haiyang Zhao,Suqing Zheng,Chengguang Zhao,Bin Chen

Journal of hepatocellular carcinoma 8:997-1021 PubMed34513744

2021

Regulation Network and Prognostic Significance of Aldo-Keto Reductase (AKR) Superfamily Genes in Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Tianxing Dai,Linsen Ye,Haoyuan Yu,Kun Li,Jing Li,Rongqiang Liu,Xu Lu,Mingbin Deng,Rong Li,Wei Liu,Yang Yang,Guoying Wang
View all publications
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Abcam product promise

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