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AB228684

Anti-AIP 抗体

Anti-AIP antibody

  • JP Deleterious:医薬用外劇物

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(1 Publication)

Rabbit Polyclonal AIP antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AIP.

別名を表示する

XAP2, AIP, AH receptor-interacting protein, Aryl-hydrocarbon receptor-interacting protein, HBV X-associated protein 2, Immunophilin homolog ARA9, XAP-2

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-AIP antibody (AB228684)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-AIP antibody (AB228684)

4% paraformaldehyde-fixed HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for AIP (green) using ab228684 at 1/500 dilution in ICC/IF.

Nuclear counterstain : Hoechst 33342 (blue).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIP antibody (AB228684)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AIP antibody (AB228684)

Paraffin-embedded mouse middle brain tissue stained for AIP using ab228684 at 1/500 dilution in immunohistochemical analysis.

Western blot - Anti-AIP antibody (AB228684)
  • WB

Supplier Data

Western blot - Anti-AIP antibody (AB228684)

10% SDS-PAGE gel.

All lanes:

Western blot - Anti-AIP antibody (ab228684) at 1/1000 dilution

All lanes:

MOLT-4 (human lymphoblastic leukemia cell line) whole cell lysate at 30 µg

Predicted band size: 37 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse, Human

アプリケーション

ICC/IF, WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human AIP. The exact immunogen used to generate this antibody is proprietary information.

O00170

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

AIP also known as aryl hydrocarbon receptor-interacting protein is a molecular chaperone with a mass of approximately 37 kDa. It mainly resides in the cytoplasm of cells and interacts with various proteins. Expression of the AIP protein occurs in many tissues including liver lung and brain. This protein plays a significant role in maintaining the stability and proper functioning of its interacting partners.
Biological function summary

AIP acts as a modulator of protein-protein interactions impacting several signaling pathways. It is a part of the larger protein complex involving heat shock proteins which helps prevent the degradation of its client proteins. AIP is essential for the activity and stability of receptors like the aryl hydrocarbon receptor (AHR) helping these receptors remain in a functional state until they get activated.

Pathways

AIP incorporates itself into the AHR signaling pathway which affects the regulation of xenobiotic metabolism. The protein is also involved in the regulation of the glucocorticoid receptor pathway working closely with proteins like Hsp90. Through these interactions AIP influences the ability of cells to respond to environmental toxins and physiological stress thereby playing a role in cellular homeostasis.

AIP has a connection with familial isolated pituitary adenomas (FIPA) and is also implicated in some forms of cancer. AIP mutations can lead to alterations in the function of the AHR receptor which is linked to these conditions. A notable interaction partner of AIP in these contexts is the pituitary tumor transforming gene (PTTG) which highlights its role in tumorigenesis and the regulation of cell proliferation.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.. Cellular negative regulator of the hepatitis B virus (HBV) X protein.
See full target information AIP
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:2221 PubMed40082403

2025

PNPLA6 regulates retinal homeostasis by choline through phospholipid turnover.

Applications

Unspecified application

Species

Unspecified reactive species

Takashi Ono,Yoshitaka Taketomi,Takayoshi Higashi,Hiroyasu Sato,Chika Mochizuki-Ono,Yuki Nagasaki,Takashi Ueta,Takashi Miyai,Suzumi M Tokuoka,Yoshiya Oda,Yasumasa Nishito,Tomio Ono,Choji Taya,Satoru Arata,Sumiko Watanabe,Tomoyoshi Soga,Tetsuya Hirabayashi,Makoto Aihara,Makoto Murakami
View all publications
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代替製品

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Western blot - Anti-AIP antibody [EPR13585] (AB192024)

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組合せ製品

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Primary Antibodies

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Western blot - Anti-Telethonin antibody [EPR8375] (AB133646)

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