Anti-AGRP 抗体 (ab113481)
Key features and details
- Rabbit polyclonal to AGRP
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-AGRP antibody
AGRP 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to AGRP -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide from internal sequence residues of Human AGRP (NM_001138.1).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Lyophilized:Reconstitute with 200ul distilled H2O. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.20
Preservative: 0.02% Sodium azide
Constituent: 1% BSA -
Concentration information loading... -
精製度
Immunogen affinity purified -
特記事項（精製）
ab113481 is purified by a peptide affinity column. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab113481の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/500 - 1/1000. Predicted molecular weight: 14 kDa.
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| 特記事項 |
|---|
|
WB
1/500 - 1/1000. Predicted molecular weight: 14 kDa. |
ターゲット情報
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機能
Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R. -
組織特異性
Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney. -
関連疾患
Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. -
配列類似性
Contains 1 agouti domain. -
ドメイン
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. -
細胞内局在
Secreted. Golgi apparatus lumen. - Information by UniProt
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参照データベース
- Entrez Gene: 181 Human
- Omim: 602311 Human
- SwissProt: O00253 Human
- Unigene: 104633 Human
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別名
- Agouti related neuropeptide antibody
- Agouti Related Protein Homolog antibody
- Agouti-related protein antibody
see all
画像
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Western blot - Anti-AGRP antibody (ab113481)All lanes : Anti-AGRP antibody (ab113481) at 1/500 dilution
Lane 1 : Human fetal brain lysate
Lane 2 : Human fetal testis lysate
Predicted band size: 14 kDa
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab113481 は 3 報の論文で使用されています。
- Chu G et al. Involvement of POMC neurons in LEAP2 regulation of food intake and body weight. Front Endocrinol (Lausanne) 13:932761 (2022). PubMed: 36387867
- Imbernon M et al. Hypothalamic KLF4 mediates leptin's effects on food intake via AgRP. Mol Metab 3:441-51 (2014). IHC-P ; Rat . PubMed: 24944903
- Lopez R et al. Hyperglycemia enhances the proliferation of non-tumorigenic and malignant mammary epithelial cells through increased leptin/IGF1R signaling and activation of AKT/mTOR. PLoS One 8:e79708 (2013). WB ; Human . PubMed: 24260287