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AB235328

Anti-AGPAT1 抗体

Anti-AGPAT1 antibody

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(1 Publication)

Rabbit Polyclonal AGPAT1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AGPAT1 aa 200 to C-terminus.

別名を表示する

G15, AGPAT1, 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha, 1-acylglycerol-3-phosphate O-acyltransferase 1, Lysophosphatidic acid acyltransferase alpha, Protein G15, 1-AGP acyltransferase 1, 1-AGPAT 1, LPAAT-alpha

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AGPAT1 antibody (AB235328)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AGPAT1 antibody (AB235328)

Paraffin-embedded human kidney tissue stained for AGPAT1 with ab235328 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AGPAT1 antibody (AB235328)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-AGPAT1 antibody (AB235328)

Paraffin-embedded human placenta tissue stained for AGPAT1 with ab235328 at 1/100 dilution in immunohistochemical analysis.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human AGPAT1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q99943

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代替製品

Primary Antibodies

AB67018

Anti-AGPAT1 antibody

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組合せ製品

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 18.2 antibody [EPR19202] (AB222512)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

AGPAT1 also known as 1-acylglycerol-3-phosphate O-acyltransferase 1 performs an important role in lipid biosynthesis. It catalyzes the conversion of lysophosphatidic acid into phosphatidic acid a precursor for glycerolipid synthesis. The molecular mass of AGPAT1 is approximately 28 kDa. AGPAT1 expresses widely in human tissues with higher levels seen in adipose tissue liver and heart.
Biological function summary

AGPAT1 impacts lipid metabolism and energy homeostasis. It participates as a single enzyme and is not typically part of larger protein complexes. By facilitating the production of phosphatidic acid it influences the balance of lipid intermediates necessary for membrane and lipoprotein synthesis. This activity affects cellular processes like membrane dynamics and signal transduction.

Pathways

AGPAT1 plays an integral role in the glycerolipid metabolism pathway. It collaborates with enzymes like lipin-1 to regulate pathways that control lipid storage and release. Its action supports the phosphatidic acid pathway which connects to various cellular signaling cascades. AGPAT1 cooperates with other proteins that modulate lipid signals bringing about effects on cell proliferation and survival.

AGPAT1 associates notably with metabolic disorders and cardiovascular diseases. Dysregulation of AGPAT1 has implications for conditions like obesity and atherosclerosis as improper lipid metabolism can lead to excess lipid accumulation or energy imbalance. AGPAT1's interaction with proteins such as lipin-1 influences these disorders where lipid imbalance and chronic inflammation become important factors.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
See full target information AGPAT1
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 10:644 PubMed31501420

2019

CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ya Liu,Xiao Zhang,Jiafei Lin,Yuxin Chen,Yongxia Qiao,Susu Guo,Yueyue Yang,Guoqing Zhu,Qiuhui Pan,Jiayi Wang,Fenyong Sun
View all publications
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