AB168355

Anti-AE binding protein 1 抗体 [EPR7733(2)]

Anti-AE binding protein 1 antibody [EPR7733(2)]

RabMAb
Recombinant
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(6 Publications)

Rabbit Recombinant Monoclonal AEBP1 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications.

別名を表示する

ACLP, AEBP1, Adipocyte enhancer-binding protein 1, AE-binding protein 1, Aortic carboxypeptidase-like protein

1 Images

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Western blot - Anti-AE binding protein 1 antibody [EPR7733(2)] (AB168355)

All lanes:

Western blot - Anti-AE binding protein 1 antibody [EPR7733(2)] (ab168355) at 1/1000 dilution

All lanes:

HepG2 cell lysate at 10 µg

Secondary

All lanes:

HRP labeled goat anti-rabbit at 1/2000 dilution

Predicted band size: 131 kDa

false

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR7733(2)

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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製品の詳細

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態

Liquid

精製度

Tissue culture supernatant

バッファー組成

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

AE binding protein 1 also known as AEBP1 functions mechanically as a transcriptional repressor. It interacts with other proteins to alter gene expression. The protein has a molecular mass of approximately 150 kDa. Researchers find AEBP1 in various tissues but expression is high in adipose tissue and the uterus. The protein's role as a repressor links to its ability to modulate the activities of certain transcription factors influencing cellular processes.

Biological function summary

AEBP1 plays a role in regulating the expression of genes important for adipogenesis and inflammation. It acts as part of a transcriptional regulation complex that controls genes driving fat cell development and lipid metabolism. Beyond adipose tissue AEBP1 also influences inflammatory responses which may connect to its function in modulating the immune system. The protein's ability to interact with intracellular pathways points to its involvement in cellular functions critical for maintaining homeostasis.

Pathways

AEBP1 integrates into the PPARγ signaling pathway. This pathway is important for adipocyte differentiation and lipid homeostasis. AEBP1's interaction with PPARγ connects it to the regulation of adipogenesis and metabolism. AEBP1 also participates indirectly in pathways modulating inflammatory responses. Through these connections AEBP1 influences proteins like C/EBPα which are key regulators of adipocyte commitment and growth.

AEBP1 has associations with obesity and inflammatory disorders. Its role in adipogenesis and inflammation links AEBP1 to obesity-related conditions where altered expression may contribute to weight gain and metabolic imbalances. Inflammatory disorders also involve AEBP1 as its modulation of immune-related factors can exacerbate or mitigate inflammation. Researchers recognize connections between AEBP1 and other proteins involved in these diseases such as NF-κB where AEBP1's regulation of inflammatory pathways could impact the progression of inflammatory diseases.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Isoform 1. As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix.. Isoform 2. May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.

See full target information AEBP1

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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:27425 PubMed39521917

2024

AEBP1 is a negative regulator of skeletal muscle cell differentiation in oral squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Fumika Okazaki,Akira Yorozu,Shohei Sekiguchi,Takeshi Niinuma,Reo Maruyama,Hiroshi Kitajima,Eiichiro Yamamoto,Kazuya Ishiguro,Mutsumi Toyota,Yui Hatanaka,Koyo Nishiyama,Kazuhiro Ogi,Masahiro Kai,Kenichi Takano,Shingo Ichimiya,Akihiro Miyazaki,Hiromu Suzuki

Cancers 15: PubMed37686580

2023

ACLP Activates Cancer-Associated Fibroblasts and Inhibits CD8+ T-Cell Infiltration in Oral Squamous Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Shohei Sekiguchi,Akira Yorozu,Fumika Okazaki,Takeshi Niinuma,Akira Takasawa,Eiichiro Yamamoto,Hiroshi Kitajima,Toshiyuki Kubo,Yui Hatanaka,Koyo Nishiyama,Kazuhiro Ogi,Hironari Dehari,Atsushi Kondo,Makoto Kurose,Kazufumi Obata,Akito Kakiuchi,Masahiro Kai,Yoshihiko Hirohashi,Toshihiko Torigoe,Takashi Kojima,Makoto Osanai,Kenichi Takano,Akihiro Miyazaki,Hiromu Suzuki

BMC oral health 22:478 PubMed36352396

2022

Inhibition of AEBP1 predisposes cisplatin-resistant oral cancer cells to ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Qianwen Zhou,Xiaoqi Wang,Yingxue Zhang,Lie Wang,Zhijun Chen

Behavioural neurology 2020:8890452 PubMed33224311

2020

AEBP1 Promotes Glioblastoma Progression and Activates the Classical NF-B Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Kai Guo,Lei Song,Jianyong Chang,Peicheng Cao,Qi Liu

Cancer science 111:1631-1644 PubMed32086986

2020

Upregulation of adipocyte enhancer-binding protein 1 in endothelial cells promotes tumor angiogenesis in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Akira Yorozu,Eiichiro Yamamoto,Takeshi Niinuma,Akihiro Tsuyada,Reo Maruyama,Hiroshi Kitajima,Yuto Numata,Masahiro Kai,Gota Sudo,Toshiyuki Kubo,Toshihiko Nishidate,Kenji Okita,Ichiro Takemasa,Hiroshi Nakase,Tamotsu Sugai,Kenichi Takano,Hiromu Suzuki

Journal of Cancer 10:4488-4498 PubMed31528213

2019

CDK5RAP3 Inhibits the Translocation of MCM6 to Influence the Prognosis in Gastric Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Qi-Yue Chen,Li-Chao Liu,Jia-Bin Wang,Jian-Wei Xie,Jian-Xian Lin,Jun Lu,Long-Long Cao,Mi Lin,Ru-Hong Tu,Chang-Ming Huang,Ping Li,Chao-Hui Zheng

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-AE binding protein 1 抗体 [EPR7733(2)]

Anti-AE binding protein 1 antibody [EPR7733(2)]

Western blot - Anti-AE binding protein 1 antibody [EPR7733(2)] (AB168355)

関連する標識済み抗体及び組成の異なる製品 (1)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製度

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (6)

組合せ製品

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise