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AB25891

Anti-Adiponectin 抗体

Anti-Adiponectin antibody

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(4 Publications)

Rabbit Polyclonal Adiponectin antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ADIPOQ.

別名を表示する

ACDC, ACRP30, APM1, GBP28, ADIPOQ, Adiponectin, 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein, Adipose most abundant gene transcript 1 protein, Gelatin-binding protein, apM-1

1 Images
Western blot - Anti-Adiponectin antibody (AB25891)
  • WB

Unknown

Western blot - Anti-Adiponectin antibody (AB25891)

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Western blot - Anti-Adiponectin antibody (ab25891) at 0.5 µg/mL

Lane 2:

Western blot - Anti-Adiponectin antibody (ab25891) at 1 µg/mL

Lane 3:

Western blot - Anti-Adiponectin antibody (ab25891) at 2 µg/mL

All lanes:

HL60 cell lysate

Predicted band size: 26 kDa

Observed band size: 26 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Synthetic Peptide within Human ADIPOQ. The exact immunogen used to generate this antibody is proprietary information.

Q15848

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Adiponectin also known as ADIPOQ or adipocyte complement-related protein of 30 kDa (Acrp30) is a 30 kDa protein that plays a significant mechanical role in energy homeostasis. Adiponectin is secreted predominantly by adipose tissue and circulates in the blood. This protein forms various multimeric structures including low-molecular-weight medium-molecular-weight and high-molecular-weight forms each with distinct biological functions. Its expression in adipose tissue links it closely to metabolic processes and functions related to fat storage and energy balance.
Biological function summary

Adiponectin influences glucose regulation and fatty acid oxidation. It acts as a hormone with several metabolic roles including anti-diabetic anti-atherogenic and anti-inflammatory properties. Adiponectin participates in forming a complex with other proteins such as AdipoR1 and AdipoR2 which are receptors facilitating signal transduction. The interaction of adiponectin with its receptors leads to the induction of several lipid and glucose metabolism pathways important for maintaining cellular energy balance.

Pathways

Many regulatory cascades are influenced by adiponectin. This protein is integral to the AMPK signaling pathway and the PPAR signaling pathway. In the AMPK pathway adiponectin enhances insulin sensitivity and stimulates oxidation of fatty acids in muscle tissue. Through the PPAR pathway it influences lipid metabolism and storage. Adiponectin interacts with key proteins such as leptin and resistin coordinating various metabolic pathways to balance energy and glucose levels making it a critical factor in metabolic regulation.

Reduced levels of adiponectin associate with conditions like type 2 diabetes and cardiovascular disease. Lower circulating adiponectin concentrations correlate with obesity leading to increased insulin resistance and higher risk of type 2 diabetes. In cardiovascular disease this protein's role links to its anti-inflammatory properties and ability to decrease the proliferation of vascular smooth muscle cells. Adiponectin also interacts with proteins like cytokines that play a role in these conditions affecting the body’s inflammatory responses and metabolic processes highlighting its importance in health and disease management.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
See full target information ADIPOQ
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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Archives of medical science : AMS 17:323-336 PubMed33747267

2021

Adipokine signatures of subcutaneous and visceral abdominal fat in normal-weight and obese women with different metabolic profiles.

Applications

Unspecified application

Species

Unspecified reactive species

Aleksandra Korac,Biljana Srdic-Galic,Andjelika Kalezic,Ana Stancic,Vesna Otasevic,Bato Korac,Aleksandra Jankovic

Molecular medicine reports 16:6170-6177 PubMed28849047

2017

Conditioned medium from tonsil‑derived mesenchymal stem cells promotes adiponectin production.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Hee Kim,Kyung-Ah Cho,Minhwa Park,Julie A Webster,So-Youn Woo,Kyung-Ha Ryu

Diabetes 57:2321-31 PubMed18599527

2008

Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36.

Applications

WB

Species

Human

Pamela M Rogers,Nazar Mashtalir,Miloni A Rathod,Olga Dubuisson,Zhong Wang,Kumar Dasuri,Scott Babin,Alok Gupta,Nathan Markward,William T Cefalu,Nikhil V Dhurandhar

The American journal of pathology 172:1069-80 PubMed18310505

2008

A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas.

Applications

WB

Species

Human

Igor Matushansky,Eva Hernando,Nicholas D Socci,Tulio Matos,Joslyn Mills,Mark A Edgar,Gary K Schwartz,Samuel Singer,Carlos Cordon-Cardo,Robert G Maki
View all publications
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代替製品

Primary Antibodies

AB181281

Anti-Adiponectin antibody [EPR17019]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-Adiponectin antibody [EPR17019] (AB181281)

  • 0
  • 0
Primary Antibodies

AB75989

Anti-Adiponectin antibody [EPR3217]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Adiponectin antibody [EPR3217] (AB75989)

  • 0
  • 0
Primary Antibodies

AB133347

Anti-Adiponectin antibody [EPR3218]

RabMAb|Recombinant

Western blot - Anti-Adiponectin antibody [EPR3218] (AB133347)

  • 0
  • 0
Primary Antibodies

AB227051

Anti-Adiponectin antibody [EPR17019] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-Adiponectin antibody [EPR17019] - BSA and Azide free (AB227051)

  • 0
  • 0

組合せ製品

Assay Kits

AB185433

Lipolysis Assay Kit (Colorimetric)

Functional Studies - Lipolysis Assay Kit (Colorimetric) (AB185433)

  • 5
  • 1
Primary Antibodies

AB181298

Anti-Leptin antibody [EPR16848-34]

RabMAb|Recombinant

Blocking - Anti-Leptin antibody [EPR16848-34] (AB181298)

  • 0
  • 0
Primary Antibodies

AB72230

Anti-PGC1 alpha + beta antibody

Immunocytochemistry/ Immunofluorescence - Anti-PGC1 alpha + beta antibody (AB72230)

  • 4
  • 2
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88

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