Anti-ADAMTS12 抗体 (ab45041)
Key features and details
- Rabbit polyclonal to ADAMTS12
- Suitable for: WB
- Reacts with: Mouse, African green monkey
- Isotype: IgG
製品の概要
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製品名
Anti-ADAMTS12 antibody
ADAMTS12 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to ADAMTS12 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, African green monkey -
免疫原
Synthetic peptide based on the propeptide region of Human ADAMTS12.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.05% Sodium azide
Constituent: 50% Glycerol -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab45041の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
特記事項 |
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ターゲット情報
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関連性
This protein is a disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAMTS12), which is a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin like domain, and a thrombospondin type 1 (TS 1) motif. Individual members of this family differ in the number of C terminal TS 1 motifs, and some have unique C terminal domains. The enzyme encoded by this gene contains 8 TS 1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. -
細胞内局在
Secreted -
参照データベース
- Entrez Gene: 239337 Mouse
- SwissProt: Q3UM66 Mouse
- SwissProt: Q3UXR3 Mouse
- SwissProt: Q811B3 Mouse
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別名
- A disintegrin and metalloproteinase with thrombospondin motifs 12 antibody
- A disintegrin like and metalloprotease with thrombospondin type 1 motif 12 antibody
- ADAM metallopeptidase with thrombospondin type 1 motif 12 antibody
- ADAM TS 12 antibody
画像
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All lanes : Anti-ADAMTS12 antibody (ab45041) at 1/1000 dilution
Lane 1 : Cell media from mouse squamous cell carcinoma KLN 205 cells (treated with TPA)
Lane 2 : Cell media from mouse squamous cell carcinoma KLN 205 cells (treated with IL1-alpha)
Lane 3 : Cell media from mouse squamous cell carcinoma KLN 205 cells (treated with TNF-alpha)
Predicted band size: 178 kDa
Full-length ADAMTS12 has been detected at 178 kDa by WB. However, study looking at ADAM-TS 12 expression in COS-7 cells (Gal et al. (2001) J. Biol. Chem. 276: 17932), has detected an 83 kD COOH-terminal cleavage product.It is possible that the post-translation processing in COS-7 cells is different than that of other cells, that the epitope tag is cleaved during processing, or that the levels of the 83 kD product in other cells were below detection.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab45041 は 1 報の論文で使用されています。
- Acar-Perk B et al. The t(14,15) in mouse strain CBA/CaH-T(14;15)6Ca/J causes a break in the ADAMTS12 gene. Comp Med 60:118-22 (2010). WB ; Mouse . PubMed: 20412686