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AB28304

Anti-ADAM23 抗体

Anti-ADAM23 antibody

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(3 Publications)

Rabbit Polyclonal ADAM23 antibody. Suitable for ICC/IF and reacts with Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ADAM23.

別名を表示する

MDC3, ADAM23, Disintegrin and metalloproteinase domain-containing protein 23, ADAM 23, MDC-3

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-ADAM23 antibody (AB28304)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ADAM23 antibody (AB28304)

ICC/IF image of ab28304 stained PC12 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab28304, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Rat

アプリケーション

ICC/IF

applications

免疫原

Synthetic Peptide within Human ADAM23. The exact immunogen used to generate this antibody is proprietary information.

O75077

特異性

ab28304 recognises the Propeptide domain of ADAM23.

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代替製品

Primary Antibodies

AB126275

Anti-ADAM23 antibody

Western blot - Anti-ADAM23 antibody (AB126275)

  • 0
  • 0
Primary Antibodies

AB28302

Anti-ADAM23 antibody - Cytoplasmic domain

Immunocytochemistry/ Immunofluorescence - Anti-ADAM23 antibody - Cytoplasmic domain (AB28302)

  • 2
  • 4

組合せ製品

Primary Antibodies

AB124695

Anti-ADAM10 antibody [EPR5622]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunoprecipitation - Anti-ADAM10 antibody [EPR5622] (AB124695)

  • 4
  • 5
Primary Antibodies

AB281583

Anti-CD31 antibody [RM1006]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [RM1006] (AB281583)

  • 5
  • 5
Primary Antibodies

AB7349

Anti-Myelin Basic Protein antibody [12] - Oligodendrocyte Marker

BOND RX™ Validated|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Myelin Basic Protein antibody [12] - Oligodendrocyte Marker (AB7349)

  • 4
  • 23
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
Preservative: 0.05% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ADAM23 also known as A Disintegrin And Metalloprotease 23 is a member of the ADAM family of proteases. This protein has a mass of approximately 95 kDa. ADAM23 is expressed in several tissues but it has a significant presence in the brain. The protein mechanically functions by engaging in protease activities though it is uniquely categorized due to its role beyond traditional proteolytic functions. It interacts with surrounding cell-matrix elements through disintegrin domains.
Biological function summary

ADAM23 plays a role in processes such as cell-cell adhesion and signal transduction. It aids in the regulation of synapse formation and maintenance in neuronal cells which is important for proper neural development and function. ADAM23 is not generally considered a part of large protein complexes but collaborates in the cellular environment impacting spatial cellular frameworks and growth signaling cascades.

Pathways

Multiple mechanisms rely on ADAM23 especially those involved in cell signaling. The protein interacts with integrin pathways influencing cellular adhesion and migration dynamics. Furthermore it works closely with other members of the ADAM family such as ADAM22 in modulating signaling pathways critical for neuronal function and transmission.

ADAM23 has shown connections to neurological conditions notably epilepsy and some types of cancer. Disruptions or mutations in the ADAM23 gene have associated alterations in nervous system activity contributing to epilepsy pathogenesis. During cancer progression ADAM23 may interact with tumor-suppressing pathways in which its family member ADAM22 also participates. Understanding ADAM23's role in these diseases can lead to new insights into therapeutic targets.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
See full target information ADAM23
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

PloS one 17:e0272277 PubMed35984846

2022

Dysregulation of the hippocampal neuronal network by LGI1 auto-antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

Elodie Fels,Marie-Eve Mayeur,Estelle Wayere,Clémentine Vincent,Céline Malleval,Jérôme Honnorat,Olivier Pascual

Frontiers in immunology 12:785247 PubMed35095860

2022

Anti-Neuronal IgG4 Autoimmune Diseases and IgG4-Related Diseases May Not Be Part of the Same Spectrum: A Comparative Study.

Applications

Unspecified application

Species

Unspecified reactive species

Verena Endmayr,Cansu Tunc,Lara Ergin,Anna De Rosa,Rosa Weng,Lukas Wagner,Thin-Yau Yu,Andreas Fichtenbaum,Thomas Perkmann,Helmuth Haslacher,Nicolas Kozakowski,Carmen Schwaiger,Gerda Ricken,Simon Hametner,Sigrid Klotz,Lívia Almeida Dutra,Christian Lechner,Désirée de Simoni,Kai-Nicolas Poppert,Georg Johannes Müller,Susanne Pirker,Walter Pirker,Aleksandra Angelovski,Matus Valach,Michelangelo Maestri,Melania Guida,Roberta Ricciardi,Florian Frommlet,Daniela Sieghart,Miklos Pinter,Karl Kircher,Gottfried Artacker,Romana Höftberger,Inga Koneczny

Neurology(R) neuroimmunology & neuroinflammation 4:e404 PubMed29075658

2017

Improving the antibody-based evaluation of autoimmune encephalitis.

Applications

Unspecified application

Species

Unspecified reactive species

Lindsey McCracken,Junxian Zhang,Maxwell Greene,Anne Crivaro,Joyce Gonzalez,Malek Kamoun,Eric Lancaster
View all publications
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