AB151992

Anti-ABCB7 抗体

Name: Anti-ABCB7 抗体 (ab151992) | Abcam
Brand: Abcam Limited
SKU: AB151992
Price: 76000 JPY
Availability: InStock

Anti-ABCB7 antibody

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(5 Publications)

Rabbit Polyclonal ABCB7 antibody. Suitable for WB and reacts with Human, Drosophila melanogaster samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ABCB7 aa 400-750.

別名を表示する

ABC7, ABCB7, ATP-binding cassette transporter 7, ABC transporter 7 protein

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human, Drosophila melanogaster

アプリケーション

applications

免疫原

Recombinant Fragment Protein within Human ABCB7 aa 400-750. The exact immunogen used to generate this antibody is proprietary information.

O75027

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Drosophila melanogaster": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ABCB7 also known as ATP-binding cassette sub-family B member 7 plays an essential role as a transporter protein involved in the transfer of iron-sulfur clusters from mitochondria to the cytosol. This protein has a mass of approximately 82 kDa and is mainly expressed in human tissues including the bone marrow and liver. The ABCB7 protein contains two nucleotide-binding domains and two transmembrane domains which facilitate its function as a processive pump across the membrane.

Biological function summary

ABCB7 is significant in maintaining cellular iron homeostasis. It integrates into a functional complex responsible for maturing iron-sulfur clusters that are critical for various cellular activities. These iron-sulfur clusters participate in numerous biochemical functions including electron transport and enzyme catalysis. Without their proper supply several cellular processes are compromised leading to metabolic dysfunctions.

Pathways

ABCB7 is integral to the biosynthesis of iron-sulfur clusters and their subsequent incorporation into proteins. This pathway involves essential collaborations with proteins such as frataxin and NFS1. The protein's role in this process affects multiple cellular processes including the mitochondrial electron transport chain and the regulation of cellular oxidative stress which are key components in the maintenance of cellular energy and redox states.

Mutations or malfunctions in ABCB7 can lead to conditions such as X-linked sideroblastic anemia and ataxia (XLSA/A). XLSA/A is marked by defective heme synthesis and increased risk of anemia due to disrupted iron-sulfur cluster biogenesis. In these diseases ABCB7 maintains direct associations with both ABCB6 and mitoferrin proteins that also play roles in iron metabolism. The genetic defects leading to dysfunctions in the ABCB7 protein result in severe metabolic consequences due to the impaired iron-sulfur cluster assembly.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis (PubMed : 10196363, PubMed : 17192393, PubMed : 33157103). Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed : 30765471). In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (By similarity).

See full target information ABCB7

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 4:138 PubMed33514783

2021

Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure.

Applications

Unspecified application

Species

Unspecified reactive species

Takaaki Furihata,Shingo Takada,Naoya Kakutani,Satoshi Maekawa,Masaya Tsuda,Junichi Matsumoto,Wataru Mizushima,Arata Fukushima,Takashi Yokota,Nobuyuki Enzan,Shouji Matsushima,Haruka Handa,Yoshizuki Fumoto,Junko Nio-Kobayashi,Toshihiko Iwanaga,Shinya Tanaka,Hiroyuki Tsutsui,Hisataka Sabe,Shintaro Kinugawa

Scientific reports 10:13988 PubMed32814794

2020

Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Agnese Po,Anna Citarella,Giuseppina Catanzaro,Zein Mersini Besharat,Sofia Trocchianesi,Francesca Gianno,Claudia Sabato,Marta Moretti,Enrico De Smaele,Alessandra Vacca,Micol Eleonora Fiori,Elisabetta Ferretti

3 Biotech 10:173 PubMed32206507

2020

Molecular evidence of impaired iron metabolism and its association with Parkinson's disease progression.

Applications

Unspecified application

Species

Unspecified reactive species

Haitao Chi,Wei Tang,Ying Bai

Haematologica 104:1756-1767 PubMed30765471

2019

Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Nunziata Maio,Ki Soon Kim,Gregory Holmes-Hampton,Anamika Singh,Tracey A Rouault

Cell metabolism 25:945-953.e6 PubMed28380382

2017

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

Applications

Unspecified application

Species

Unspecified reactive species

Nunziata Maio,Ki Soon Kim,Anamika Singh,Tracey A Rouault

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ABCB7 抗体

Anti-ABCB7 antibody

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (5)

Abcam product promise