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AB203120

Anti-ABCB5 抗体

Anti-ABCB5 antibody

4

(1 Review)

|

(2 Publications)

Rabbit Polyclonal ABCB5 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ATP-binding cassette sub-family B member 5 aa 1200 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

ATP-binding cassette sub-family B member 5, ABCB5 P-gp, P-glycoprotein ABCB5, ABCB5

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB5 antibody (AB203120)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB5 antibody (AB203120)

Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded mouse melanoma tissue sections labeling ABCB5 with ab203120 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse

アプリケーション

IHC-P

applications

免疫原

Synthetic Peptide within Human ATP-binding cassette sub-family B member 5 aa 1200 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q2M3G0

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代替製品

Primary Antibodies

AB77549

Anti-ABCB5 antibody

Western blot - Anti-ABCB5 antibody (AB77549)

  • 0
  • 0
Primary Antibodies

AB197406

Anti-ABCB5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB5 antibody (AB197406)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB211464

Anti-NECAB2 antibody [CL0524]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NECAB2 antibody [CL0524] (AB211464)

  • 0
  • 0
Primary Antibodies

AB229193

Anti-BCRP/ABCG2 antibody [EPR21122]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-BCRP/ABCG2 antibody [EPR21122] (AB229193)

  • 0
  • 0
Primary Antibodies

AB170904

Anti-P Glycoprotein antibody [EPR10364-57]

20ul selling size|RabMAb|Recombinant|KO Validated

Western blot - Anti-P Glycoprotein antibody [EPR10364-57] (AB170904)

  • 4
  • 12
Primary Antibodies

AB124964

Anti-alpha smooth muscle Actin antibody [EPR5368]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [EPR5368] (AB124964)

  • 5
  • 19
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ABCB5 also known as ATP-binding cassette sub-family B member 5 belongs to the ABC transporter family. This protein functions mechanically as a transmembrane transporter that moves various molecules across cellular membranes using ATP hydrolysis. ABCB5 has a molecular mass of approximately 81 kDa. It is primarily expressed in stem cells melanocytes and certain cancer cells notably in the skin and eye tissues.
Biological function summary

ABCB5 plays an essential role in the regulation of cellular processes including development proliferation and differentiation. It is part of the ATP-binding cassette transporters which help in maintaining cellular homeostasis by exporting toxic substances out of cells. In stem cells ABCB5 maintains the undifferentiated state and protects cells from apoptosis by mediating efflux of drugs contributing to multidrug resistance.

Pathways

ABCB5 interacts with several cellular pathways involved in cell survival and drug resistance. It is closely connected with the Wnt/beta-catenin signaling pathway which regulates cell proliferation and differentiation. ABCB5 also interacts with proteins like P-glycoprotein (ABCB1) as they both participate in similar drug resistance mechanisms affecting therapeutic outcomes in cancer treatment.

Research links ABCB5 to cancer progression and treatment resistance especially in melanoma and colorectal cancer. Its overexpression associates with chemotherapy resistance indicating a need for targeted therapy approaches. In melanoma proteins such as CD133 and ABCB5 together contribute to maintaining cancer stem cell populations which can lead to metastasis and recurrence.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells (PubMed : 12960149, PubMed : 15205344, PubMed : 15899824, PubMed : 22306008). Specifically present in limbal stem cells, where it plays a key role in corneal development and repair (By similarity).
See full target information ATP-binding cassette sub-family B member 5
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Neural regeneration research 21:333-345 PubMed40489346

2025

Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress.

Applications

Unspecified application

Species

Unspecified reactive species

Yumei Liao,Qinghua Zhang,Qiaoyun Shi,Peng Liu,Peiyun Zhong,Lingling Guo,Zijian Huang,Yinghui Peng,Wei Liu,Shiqing Zhang,István Adorján,Yumi Fukuzaki,Eri Kawashita,Xiao-Qi Zhang,Nan Ma,Xiaoshen Zhang,Zoltán Molnár,Lei Shi

International journal of cancer 146:192-207 PubMed31107974

2019

Wnt/IL-1β/IL-8 autocrine circuitries control chemoresistance in mesothelioma initiating cells by inducing ABCB5.

Applications

Unspecified application

Species

Unspecified reactive species

Vladan Milosevic,Joanna Kopecka,Iris C Salaroglio,Roberta Libener,Francesca Napoli,Stefania Izzo,Sara Orecchia,Preeta Ananthanarayanan,Paolo Bironzo,Federica Grosso,Fabrizio Tabbò,Valentina Comunanza,Teodora Alexa-Stratulat,Federico Bussolino,Luisella Righi,Silvia Novello,Giorgio V Scagliotti,Chiara Riganti
View all publications
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Abcam product promise

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