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AB231535

Anti-ABCB10 抗体

Anti-ABCB10 antibody

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(3 Publications)

Rabbit Polyclonal ABCB10 antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ABCB10 aa 450 to C-terminus.

別名を表示する

ABC-mitochondrial erythroid protein, ATP-binding cassette transporter 10, Mitochondrial ATP-binding cassette 2, ABC-me protein, ABC transporter 10 protein, M-ABC2, ABCB10

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB10 antibody (AB231535)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ABCB10 antibody (AB231535)

Formalin-fixed, paraffin-embedded human liver tissue stained for ABCB10 using ab231535 at 20μg/ml in immunohistochemical analysis. DAb staining.

Western blot - Anti-ABCB10 antibody (AB231535)
  • WB

Supplier Data

Western blot - Anti-ABCB10 antibody (AB231535)

All lanes:

Western blot - Anti-ABCB10 antibody (ab231535) at 2 µg/mL

All lanes:

Pig liver lysate

Predicted band size: 79 kDa

false

Western blot - Anti-ABCB10 antibody (AB231535)
  • WB

Supplier Data

Western blot - Anti-ABCB10 antibody (AB231535)

All lanes:

Western blot - Anti-ABCB10 antibody (ab231535) at 2 µg/mL

All lanes:

Recombinant human ABCB10 protein.

Predicted band size: 79 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human, Pig

アプリケーション

IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Human ABCB10 aa 450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NRK6

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代替製品

Primary Antibodies

AB74815

Anti-ABCB10 antibody

Western blot - Anti-ABCB10 antibody (AB74815)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB151992

Anti-ABCB7 antibody

  • 0
  • 0
Primary Antibodies

AB232767

Anti-DHODH antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DHODH antibody (AB232767)

  • 0
  • 0
Primary Antibodies

AB151754

Anti-ALAD antibody [EPR10268(B)]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALAD antibody [EPR10268(B)] (AB151754)

  • 0
  • 0
Proteins & Peptides

AB79941

Recombinant Human ALAS2/ASB protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human ALAS2/ASB protein (His tag N-Terminus) (AB79941)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
ab231535 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ABCB10 also known as ATP-binding cassette sub-family B member 10 plays a role as a transport protein involved in the mitochondrial export of molecules. It is a member of the ABC (ATP-binding cassette) transporter family characterized by its ability to move various substrates across membranes using ATP hydrolysis. ABCB10 has a molecular mass of approximately 81 kDa and is expressed mainly in the mitochondria of cells with significant levels in tissues with high metabolic activity like the heart and liver.
Biological function summary

ABCB10 contributes to important cellular functions by participating in heme synthesis. It interacts with other mitochondrial proteins forming complexes that facilitate the import of iron and export of heme precursors. This interaction ensures the maintenance of proper heme levels which are necessary for diverse cellular processes including respiration and detoxification pathways. Its activity is not isolated but connected to broader protein networks within the mitochondrial intermembrane space.

Pathways

ABCB10 participates in the heme biosynthesis pathway which is essential for the production of hemoproteins including hemoglobin and cytochromes. Within this context ABCB10 works closely with proteins such as ferrochelatase which catalyzes the final step in heme production. Another related pathway is oxidative phosphorylation where ABCB10 indirectly sustains energy production by ensuring the availability of heme for cytochrome assembly which is pivotal for electron transport chain function.

ABCB10 plays a significant role in conditions related to mitochondrial dysfunction such as sideroblastic anemia and cardiovascular diseases. Mutations affecting ABCB10 can disrupt normal heme synthesis impacting red blood cell production and leading to anemia. Additionally improper function of ABCB10 influences iron homeostasis which associates with proteins like ALAS2 (aminolevulinate synthase 2) further contributing to erythropoietic disorders and highlighting its role in iron-related pathologies.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress (PubMed : 22085049, PubMed : 28315685, PubMed : 28808058, PubMed : 34011630, PubMed : 37041204). Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX) (PubMed : 22085049, PubMed : 28808058). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37 (By similarity). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (PubMed : 28315685).
See full target information ABCB10
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Antioxidants (Basel, Switzerland) 10: PubMed34943057

2021

Mito-TIPTP Increases Mitochondrial Function by Repressing the Rubicon-p22phox Interaction in Colitis-Induced Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jae-Sung Kim,Ye-Ram Kim,Sein Jang,Sang Geon Wang,Euni Cho,Seok-Jun Mun,Hye-In Jeon,Hyo-Keun Kim,Sun-Joon Min,Chul-Su Yang

Frontiers in cell and developmental biology 9:688070 PubMed34386493

2021

Surface PEGylated Cancer Cell Membrane-Coated Nanoparticles for Codelivery of Curcumin and Doxorubicin for the Treatment of Multidrug Resistant Esophageal Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Gao,Yue Zhu,Xiaopeng Xu,Fangjun Wang,Weidong Shen,Xia Leng,Jiyi Zhao,Bingtuan Liu,Yangyun Wang,Pengfei Liu

Drug development research 82:115-122 PubMed32820830

2020

The involvement of protein TNFSF18 in promoting p-STAT1 phosphorylation to induce coronary microcirculation disturbance in atherosclerotic mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Gao,Sai Wang,Shilei Liu
View all publications
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