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AB3505

Anti-AANAT 抗体

Anti-AANAT antibody

0

(1 Review)

|

(17 Publications)

Rabbit Polyclonal AANAT antibody. Suitable for WB, IHC-P and reacts with Rat samples. Cited in 17 publications. Immunogen corresponding to Synthetic Peptide within Mouse Aanat aa 1-50.

別名を表示する

Snat, Aanat, Serotonin N-acetyltransferase, Serotonin acetylase, Aralkylamine N-acetyltransferase, AA-NAT

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Rat

アプリケーション

IHC-P, WB

applications

免疫原

Synthetic Peptide within Mouse Aanat aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

O88816

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Reactivity data

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
Total anti-N-terminal AA-NAT-specific IgG was affinity purified on resin-coupled non-phosphopeptide. Phospho-specific amino-terminal IgG was subsequently isolated on resin-coupled phosphopeptide.
バッファー組成
Preservative: 0.05% Sodium azide Constituents: 99% PBS, 0.1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

AANAT also known as aralkylamine N-acetyltransferase or serotonin N-acetyltransferase is an enzyme with a molecular mass of approximately 23.3 kDa. This enzyme catalyzes the transfer of an acetyl group from acetyl-CoA to serotonin forming N-acetylserotonin. AANAT expression is mainly found in the pineal gland where it acts as an important player in melatonin biosynthesis. The function of AANAT as a regulatory point in this biosynthesis contributes to the role of melatonin in circadian rhythms and sleep regulation.
Biological function summary

AANAT has a critical role in regulating physiological processes through the production of melatonin. It operates as part of the intramolecular complex that facilitates its enzymatic activity in the pineal gland. By converting serotonin into N-acetylserotonin which further converts to melatonin AANAT modulates the synthesis of melatonin an indoleamine with effects on sleep-wake cycles and seasonal reproductive rhythms in mammals. This regulatory activity reflects how AANAT influences the hormonal signaling pathways in response to light and dark cycles.

Pathways

AANAT is integral to the melatonin synthesis pathway and interacts closely in serotonin metabolism. It tightly regulates the conversion of serotonin to melatonin in the pineal gland especially during nocturnal periods. One key protein related to AANAT in this pathway is hydroxyindole O-methyltransferase (HIOMT) which converts N-acetylserotonin to melatonin. The modulation of melatonin levels impacts diverse biological pathways including circadian rhythm regulation and neuroendocrine signaling.

AANAT plays a significant role in conditions like seasonal affective disorder (SAD) and sleep disturbances. Alterations in AANAT expression or function can affect melatonin levels leading to these disorders. Additionally disruptions in the enzymatic activity of AANAT may have interactions with serotonin influencing its availability and potentially linking it to disorders like depression. Understanding AANAT's function allows researchers to explore therapeutic strategies targeting melatonin pathways in managing these conditions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
See full target information Aanat
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文献 (17)

Recent publications for all applications. Explore the full list and refine your search

Journal of pineal research 75:e12885 PubMed37183291

2023

RP58 knockdown contributes to hypoxia-ischemia-induced pineal dysfunction and circadian rhythm disruption in neonatal rats.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Yang,Zubin Zhang,Xin Ding,Xiaolu Jiang,Lanlan Tan,Chenjie Lin,Lixiao Xu,Gen Li,Lianghua Lu,Zhenghong Qin,Xing Feng,Mei Li

International journal of molecular sciences 24: PubMed37108290

2023

The Uterine Melatonergic Systems of AANAT and Melatonin Membrane Receptor 2 (MT2) Are Essential for Endometrial Receptivity and Early Implantation in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Ma,Jing Wang,Likai Wang,Laiqing Yan,Yunjie Liu,Wenkui Ma,Pengyun Ji,Lu Zhang,Guoshi Liu

Antioxidants (Basel, Switzerland) 12: PubMed36978937

2023

Melatonin Supplementation during the Late Gestational Stage Enhances Reproductive Performance of Sows by Regulating Fluid Shear Stress and Improving Placental Antioxidant Capacity.

Applications

Unspecified application

Species

Unspecified reactive species

Likai Wang,Laiqing Yan,Qi Han,Guangdong Li,Hao Wu,Xiao Ma,Mengmeng Zhao,Wenkui Ma,Pengyun Ji,Ran Zhang,Guoshi Liu

International journal of molecular sciences 23: PubMed36555116

2022

Circ-ERC2 Is Involved in Melatonin Synthesis by Regulating the miR-125a-5p/MAT2A Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Hai-Xiang Guo,Yi Zheng,Guo-Kun Zhao,Hao-Qi Wang,Song Yu,Fei Gao,Jia-Bao Zhang,Yong-Hong Zhang,Bao Yuan

Cellular and molecular gastroenterology and hepatology 14:877-904 PubMed35863741

2022

Prolonged Administration of Melatonin Ameliorates Liver Phenotypes in Cholestatic Murine Model.

Applications

Unspecified application

Species

Unspecified reactive species

Ludovica Ceci,Lixian Chen,Leonardo Baiocchi,Nan Wu,Lindsey Kennedy,Guido Carpino,Konstantina Kyritsi,Tianhao Zhou,Travis Owen,Debjyoti Kundu,Amelia Sybenga,Abdulkadir Isidan,Burcin Ekser,Antonio Franchitto,Paolo Onori,Eugenio Gaudio,Romina Mancinelli,Heather Francis,Gianfranco Alpini,Shannon Glaser

Nutrients 14: PubMed35010992

2021

Increases Intestinal Melatonin Level by Activating p-CREB-AANAT Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Lijin Song,Meibo He,Qinghua Sun,Yujing Wang,Jindong Zhang,Yuan Fang,Shuangjiang Liu,Liping Duan

Communications biology 4:534 PubMed33958705

2021

Melatonin delays ovarian aging in mice by slowing down the exhaustion of ovarian reserve.

Applications

Unspecified application

Species

Unspecified reactive species

Chan Yang,Qinghua Liu,Yingjun Chen,Xiaodong Wang,Zaohong Ran,Fang Fang,Jiajun Xiong,Guoshi Liu,Xiang Li,Liguo Yang,Changjiu He

Frontiers in cell and developmental biology 9:648148 PubMed33937242

2021

Melatonin Alleviates the Suppressive Effect of Hypoxanthine on Oocyte Nuclear Maturation and Restores Meiosis via the Melatonin Receptor 1 (MT1)-Mediated Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Wang,Zhiyong Zhuo,Xiao Ma,Yunjie Liu,Jing Xu,Changjiu He,Yao Fu,Feng Wang,Pengyun Ji,Lu Zhang,Guoshi Liu

Biology of reproduction 104:1322-1336 PubMed33709108

2021

Melatonin promotes male reproductive performance and increases testosterone synthesis in mammalian Leydig cells†.

Applications

Unspecified application

Species

Unspecified reactive species

Minghui Yang,Shengyu Guan,Jingli Tao,Kuanfeng Zhu,Dongying Lv,Jing Wang,Guangdong Li,Yuefeng Gao,Hao Wu,Jinghao Liu,Lin Cao,Yao Fu,Pengyun Ji,Zhengxing Lian,Lu Zhang,Guoshi Liu

Genomics, proteomics & bioinformatics 18:708-720 PubMed33607299

2021

Increased Expression of Colonic Mucosal Melatonin in Patients with Irritable Bowel Syndrome Correlated with Gut Dysbiosis.

Applications

Unspecified application

Species

Unspecified reactive species

Ben Wang,Shiwei Zhu,Zuojing Liu,Hui Wei,Lu Zhang,Meibo He,Fei Pei,Jindong Zhang,Qinghua Sun,Liping Duan
View all publications
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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