Anti-5HT1A Receptor 抗体 (ab64994)
Key features and details
- Rabbit polyclonal to 5HT1A Receptor
- Suitable for: WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
製品の概要
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製品名
Anti-5HT1A Receptor antibody
5HT1A Receptor 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to 5HT1A Receptor -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Rat, Human -
免疫原
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading... -
精製度
Immunogen affinity purified -
特記事項（精製）
ab64994 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab64994の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (1) |
1/500 - 1/1000. Detects a band of approximately 46 kDa (predicted molecular weight: 46 kDa).
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| 特記事項 |
|---|
|
WB
1/500 - 1/1000. Detects a band of approximately 46 kDa (predicted molecular weight: 46 kDa). |
ターゲット情報
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機能
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. -
配列類似性
Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 3350 Human
- Entrez Gene: 15550 Mouse
- Entrez Gene: 24473 Rat
- Omim: 109760 Human
- SwissProt: P08908 Human
- SwissProt: Q64264 Mouse
- SwissProt: P19327 Rat
- Unigene: 247940 Human
see all -
別名
- 5 HT 1A antibody
- 5 HT receptor 1A antibody
- 5 HT1A antibody
see all
画像
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Western blot - Anti-5HT1A Receptor antibody (ab64994)All lanes : Anti-5HT1A Receptor antibody (ab64994) at 1/500 dilution
Lane 1 : Extracts from HepG2 cells with no immunising peptide
Lane 2 : Extracts from Jurkat cells with no immunising peptide
Lane 3 : Extracts from Jurkat cells with immunising peptide at 5 µg
Lysates/proteins at 5 µg per lane.
Predicted band size: 46 kDa
Observed band size: 46 kDa
Additional bands at: 105 kDa. We are unsure as to the identity of these extra bands. -
Western blot - Anti-5HT1A Receptor antibody (ab64994)All lanes : Anti-5HT1A Receptor antibody (ab64994) at 1 µg/ml
Lane 1 : Human brain tissue lysate - total protein (ab29466)
Lane 2 : Brain (Mouse) Tissue Lysate (ab27253)
Lane 3 : Brain (Rat) Tissue Lysate (ab7942)
Predicted band size: 46 kDa
Observed band size: 46 kDa
Additional bands at: 52 kDa, 85 kDa. We are unsure as to the identity of these extra bands.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab64994 は 4 報の論文で使用されています。
- Gorinski N et al. Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors. Nat Commun 10:3924 (2019). PubMed: 31477731
- Rodríguez-Muñoz M et al. Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. Oncotarget 9:23373-23389 (2018). PubMed: 29805740
- Fonseca NC et al. 5-hydroxytryptamine1A receptor density in the hippocampus of patients with temporal lobe epilepsy is associated with disease duration. Eur J Neurol 24:602-608 (2017). PubMed: 28188677
- Riksen EA et al. Serotonin and fluoxetine receptors are expressed in enamel organs and LS8 cells and modulate gene expression in LS8 cells. Eur J Oral Sci 118:566-73 (2010). PubMed: 21083617