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AB86575

Anti-4-1BBL 抗体 [RM0067-3H19]

Anti-4-1BBL antibody [RM0067-3H19]

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(2 Publications)

Rat Monoclonal 4-1BBL antibody. Suitable for Flow Cyt, WB and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Tnfsf9.

別名を表示する

Cd137l, Cd157l, Ly63l, Tnfsf9, Tumor necrosis factor ligand superfamily member 9, 4-1BB ligand, 4-1BBL

Key facts

宿主種

Rat

クローン性

Monoclonal

クローン番号

RM0067-3H19

アイソタイプ

IgG2

キャリアフリー

No

交差種

Mouse

アプリケーション

Flow Cyt, WB

applications

免疫原

Recombinant Fragment Protein within Mouse Tnfsf9. The exact immunogen used to generate this antibody is proprietary information.

P41274

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The 4-1BBL protein also known as CD137L or 4-1BB ligand acts mechanically as a member of the tumor necrosis factor (TNF) superfamily. The 4-1BBL with a mass of around 36 kDa exists as a type II transmembrane protein. It gets expressed on activated antigen-presenting cells like dendritic cells macrophages and B cells. This costimulatory molecule primarily interacts with its receptor 4-1BB (CD137) on T cells promoting their activation.
Biological function summary

The 4-1BBL protein plays an important role in mediating the co-stimulatory signal needed for T-cell proliferation survival and cytokine production. This protein contributes to the formation of the immunological synapse and doesn't exist alone but rather interacts directly with its receptor CD137 forming a receptor-ligand complex. The 4-1BBL-CD137 interaction strengthens signals delivered by the T-cell receptor enhancing immune responses.

Pathways

The 4-1BBL protein integrates into immune-related signaling pathways. It significantly impacts the NF-kB and MAPK pathways important for T cell survival and activation. The interaction between 4-1BBL and its related proteins such as the 4-1BB/CD137 receptor initiates downstream cascades that lead to the activation of transcription factors involved in immune response.

The 4-1BBL protein connects to conditions such as cancer and autoimmune diseases. Overexpression or dysregulation of 4-1BBL has associations with autoimmune conditions like rheumatoid arthritis due to prolonged T cell activation. In cancer 4-1BBL's interaction with CD137 has potential therapeutic implications with efforts to harness this axis to bolster anti-tumor immunity. The modulation of 4-1BBL activity can influence disease outcomes highlighting its significance as a target for therapeutic interventions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
See full target information Tnfsf9
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cancers 11: PubMed30650588

2019

A DNA Vaccine Encoding SA-4-1BBL Fused to HPV-16 E7 Antigen Has Prophylactic and Therapeutic Efficacy in a Cervical Cancer Mouse Model.

Applications

Unspecified application

Species

Unspecified reactive species

Rodolfo Garza-Morales,Jose J Perez-Trujillo,Elvis Martinez-Jaramillo,Odila Saucedo-Cardenas,Maria J Loera-Arias,Aracely Garcia-Garcia,Humberto Rodriguez-Rocha,Esma Yolcu,Haval Shirwan,Jorge G Gomez-Gutierrez,Roberto Montes-de-Oca-Luna

Cancer immunology research 4:766-78 PubMed27364122

2016

Gp96-Ig/Costimulator (OX40L, ICOSL, or 4-1BBL) Combination Vaccine Improves T-cell Priming and Enhances Immunity, Memory, and Tumor Elimination.

Applications

Unspecified application

Species

Unspecified reactive species

George Fromm,Suresh de Silva,Louise Giffin,Xin Xu,Jason Rose,Taylor H Schreiber
View all publications
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代替製品

Primary Antibodies

AB254385

Anti-4-1BBL antibody [EPR21995-147]

RabMAb|Recombinant

Flow Cytometry - Anti-4-1BBL antibody [EPR21995-147] (AB254385)

  • 0
  • 0
Primary Antibodies

AB223160

Anti-4-1BBL antibody [CD137L/1547]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-4-1BBL antibody [CD137L/1547] (AB223160)

  • 0
  • 0
Primary Antibodies

AB64912

Anti-4-1BBL antibody

Immunocytochemistry/ Immunofluorescence - Anti-4-1BBL antibody (AB64912)

  • 0
  • 0
Primary Antibodies

AB203291

Anti-4-1BBL antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-4-1BBL antibody (AB203291)

  • 0
  • 0
Primary Antibodies

AB68185

Anti-4-1BBL antibody [EPR1172Y]

RabMAb|Recombinant

Western blot - Anti-4-1BBL antibody [EPR1172Y] (AB68185)

  • 0
  • 0
Primary Antibodies

AB199523

HRP Anti-4-1BBL antibody [EPR1172Y]

RabMAb|Recombinant

Western blot - HRP Anti-4-1BBL antibody [EPR1172Y] (AB199523)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB243648

Anti-CD137 antibody [EPR23218-111]

RabMAb|Recombinant

Flow Cytometry - Anti-CD137 antibody [EPR23218-111] (AB243648)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Flow Cytometry - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB229021

Anti-CD134 / OX40L receptor antibody [EPR22229-5]

BOND RX™ Validated|RabMAb|Recombinant

Flow Cytometry - Anti-CD134 / OX40L receptor antibody [EPR22229-5] (AB229021)

  • 5
  • 1
Primary Antibodies

AB275858

Anti-OX40L/TNFSF4 antibody [EPR23155-317] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-OX40L/TNFSF4 antibody [EPR23155-317] - BSA and Azide free (Capture) (AB275858)

  • 0
  • 0

Abcam product promise

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