AB108757

Human Anti-Parainfluenza virus 1,2,3 IgA ELISA Kit

Name: Human Anti-Parainfluenza virus 1,2,3 IgA ELISA Kit (ab108757) | Abcam
Brand: Abcam Limited
SKU: AB108757
Price: 141000 JPY
Availability: InStock

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Human Anti-Parainfluenza virus 1,2,3 IgA ELISA Kit is an indirect ELISA for the qualitative detection of IgA class antibodies against Parainfluenza virus 1,2,3 in human plasma and serum samples.

- Colorimetric readout - 450 nm - Works on any standard plate reader
- Easy results interpretation
- Cut-off, positive and negative controls included

Key facts

検出方法

Colorimetric

サンプルタイプ

Citrate plasma, Heparin Plasma, Serum

交差種

Human

アッセイタイプ

Indirect

アッセイプラットフォーム

Microplate

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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製品の詳細

Abcam's anti-Parainfluenza virus 1, 2, 3 IgA Human in vitro ELISA (Enzyme-Linked Immunosorbent Assay) kit is designed for the accurate qualitative measurement of IgA class antibodies against Parainfluenza virus 1, 2, 3 in Human serum and plasma.

A 96-well plate has been precoated with Parainfluenza virus 1, 2, 3 antigens to bind cognate antibodies. Controls or test samples are added to the wells and incubated. Following washing, a horseradish peroxidase (HRP) labelled anti-Human IgA conjugate is added to the wells, which binds to the immobilized Parainfluenza virus 1, 2, 3-specific antibodies. TMB is then catalyzed by the HRP to produce a blue color product that changes to yellow after adding an acidic stop solution. The density of yellow coloration is directly proportional to the amount of Parainfluenza virus 1, 2, 3 IgA sample captured in plate.

REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.

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精度

[ { "reproducibilityType": "Inter", "sample": "Serum", "replicates": 24, "mean": null, "standardDeviation": null, "coefficientOfVariability": "5.1" }, { "reproducibilityType": "Intra", "sample": "Serum", "replicates": 8, "mean": null, "standardDeviation": null, "coefficientOfVariability": "2.6" } ]

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製品内容

{ "values": { "1x96Tests": { "sellingSize": "1 x 96 Tests", "publicAssetCode":"ab108757-1x96Tests", "assetComponentDetails": [ { "size":"1 x 3 mL", "name":"Parainfluenza virus 1, 2, 3 IgA Cut-off Control", "number":"AB108757-CMP04", "productcode":"" }, { "size":"1 x 2 mL", "name":"Parainfluenza virus 1, 2, 3 IgA Positive Control", "number":"AB108757-CMP03", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Parainfluenza virus 1, 2, 3 (IgA) Coated Microplate (12 x 8 wells)", "number":"AB108757-CMP02", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Cover foil", "number":"AB108757-CMP07", "productcode":"" }, { "size":"1 x 1 Unit", "name":"Strip holder", "number":"AB108757-CMP06", "productcode":"" }, { "size":"1 x 50 mL", "name":"20X Washing Solution", "number":"AB108757-CMP10", "productcode":"" }, { "size":"1 x 15 mL", "name":"TMB Substrate Solution", "number":"AB108757-CMP08", "productcode":"" }, { "size":"1 x 20 mL", "name":"Parainfluenza virus 1, 2, 3 anti-IgA HRP Conjugate", "number":"AB108757-CMP01", "productcode":"" }, { "size":"1 x 100 mL", "name":"IgA Sample Diluent", "number":"AB108757-CMP09", "productcode":"" }, { "size":"1 x 15 mL", "name":"Stop Solution", "number":"AB108757-CMP11", "productcode":"" }, { "size":"1 x 2 mL", "name":"Parainfluenza virus 1, 2, 3 IgA Negative Control", "number":"AB108757-CMP05", "productcode":"" } ] } } }

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出荷温度及び保存条件

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

保管に関する情報

+4°C

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Parainfluenza Virus IgA also known as Immunoglobulin A specific to Parainfluenza Virus plays a mechanical role in the immune system as an important antibody type produced primarily in mucosal membranes. IgA is a dimeric molecule with a mass of approximately 385 kDa and it is expressed in mucosal-associated tissues including the respiratory and gastrointestinal tracts. It is recognized for its ability to mediate immune exclusion by binding to pathogens like the Parainfluenza Virus preventing their attachment and subsequent entry into host cells.

Biological function summary

The immune response involving secretory IgA is essential for neutralizing pathogens in the mucosal surfaces. IgA acts independently or as part of the immunoglobulin complex to protect epithelial cells from viral infections. By binding to Parainfluenza Virus antigens IgA prevents the spread of infection and contributes to immune homeostasis in the mucosal linings. This function helps to maintain a balance in immune signaling and cellular activation ensuring the proper function of the mucosal barriers.

Pathways

IgA secretion impacts both mucosal immunity and inflammation regulation. It participates in the mucosal immune pathway influencing processes such as antigen presentation and lymphocyte activation. IgA works in conjunction with other immune proteins like IgG and components of the complement pathway. These interactions not only reinforce mucosal immunity but also modulate systemic immune responses reflecting IgA's involvement in broader immune regulation.

IgA provides important defense against infections such as Parainfluenza which can lead to respiratory illnesses like croup and bronchiolitis. IgA levels often reflect the host's defense capacity against such infections. In some cases IgA interactions with other proteins like secretory component SC and J chain become important in managing excessive stimulation or deficiency which are linked to disorders like selective IgA deficiency. Understanding these dynamics could help in diagnosing and treating conditions associated with Parainfluenza Virus and related respiratory diseases.

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製品プロトコール

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ターゲットの情報

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websiteProtocolBooklet

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Abcam product promise

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Human Anti-Parainfluenza virus 1,2,3 IgA ELISA Kit