Human APOL6 knockout A549 cell lysate
Human APOL6 knockout A549 cell lysate
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APOL6 KO cell lysate available now. KO validated. Free of charge wild type control included. Knockout achieved by using CRISPR/Cas9, 1 bp deletion in exon2.
別名を表示する
2310076O14Rik, APOL6_HUMAN, ApoL-VI, Apolipoprotein L, 6, Apolipoprotein L-VI, Apolipoprotein L6, DKFZp667M075, FLJ38562, FLJ90164, MGC57495
- Sanger seq
Unknown
Sanger Sequencing - Human APOL6 knockout A549 cell lysate (AB263093)
Homozygous : 1 bp deletion in exon2
製品の詳細
Knockout cell lysate achieved by CRISPR/Cas9.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Lysate preparation: Our lysates are made using RIPA buffer to which we add a protease inhibitor cocktail and phosphatase inhibitor cocktail (ratio: 300:100:10). This means that the protein of interest is denatured. If you require a native form of the protein please use the live cell version. Please refer to our lysis protocol for further details on how our lysates are prepared.
User storage instructions: Lyophilizate may be stored at 4°C. After reconstitution, store at -20°C for short-term storage or -80°C for long-term storage.
This product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our limited use license and patent pages.
製品内容
出荷温度及び保存条件
遺伝子名
遺伝子編集のタイプ
遺伝子編集の方法
ノックアウト検証方法
出荷温度
短期保存温度
長期保存温度
補足情報
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
APOL6 influences important cellular processes such as apoptosis and lipid metabolic processes. Although not part of a large protein complex APOL6 contributes significantly to the regulation of phospholipid transport and stability within cellular membranes. Through these functions APOL6 supports cellular homeostasis and impacts the regulation of cell death pathways.
Pathways
Lipid metabolism and cell signaling heavily involve APOL6. It interacts with other apolipoproteins and factors like cholesterol transport proteins. Within the lipid metabolic pathway APOL6 facilitates proper lipid transport working closely with apolipoprotein E (ApoE) which is another key player in these processes. Disruption of this interaction can lead to imbalances in lipid homeostasis affecting overall health.
Quality control
STR analysis
CSF1PO, D13S317, D7S820, D5S818, TH01, D16S539, TPOX
Cell culture
Biosafety level
EU: 1 US: 1
Adherent/suspension
Adherent
Gender
Male
組合せ製品
Abcam product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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