VO-OHpic trihydrate, PTEN inhibitor

Key facts

精製度

>98%

製品の状態

Solid

form

分子量

417.22 Da

分子式

C₁₂H₁₈N₂O₁₁V+

PubChem

66577002

由来

Synthetic

溶解性

Soluble in DMSO to 25 mM

化学名

Hydron;hydroxy(oxo)vanadium;3-hydroxypyridine-2-carboxylic acid;trihydrate

生物学的記述

Potent, selective and reversible PTEN inhibitor (IC₅₀ = 46 nM). Increases PIP3 levels, phosphorylation of Akt and glucose uptake. Active in vivo.

Canonical smiles

[H+].C1=CC(=C(N=C1)C(=O)O)O.C1=CC(=C(N=C1)C(=O)O)O.O.O.O.O[V]=O

InChi

InChI=1S/2C6H5NO3.4H2O.O.V/c2*8-4-2-1-3-7-5(4)6(9)10;;;;;;/h2*1-3,8H,(H,9,10);4*1H2;;/q;;;;;;;+1

InChiKey

OWDNSCJMZFXFMO-UHFFFAOYSA-N

IUPAC名

hydron;hydroxy(oxo)vanadium;3-hydroxypyridine-2-carboxylic acid;trihydrate