Vatalanib dihydrochloride, VEGFR tyrosine kinase inhibitor (ab142199)

Cell-permeable, potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1) and VEGFR-2 (FLK-1/KDR) (IC₅₀ values are 77 nM and 37 nM respectively). Weaker inhibitor of other tyrosine kinases including PDGFR-β, c-KIT, VEGFR-3 (FLT-4) and c-FMS (IC₅₀ values are 580 nM, 730 nM, 660 nM and 1.4 μM respectively). Inactive against EGFR, c-SRC, v-ABL, and protein kinase Cα (IC₅₀ > 10 μM). Induces dose-dependent inhibition of VEGF and PDGF-induced angiogenesis in a growth factor implant model.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Synthetic

• Epigenetics and Nuclear Signaling
• Transcription
• Domain Families
• HLH / Leucine Zipper
• Helix-Turn-Helix

• Neuroscience
• Development

• Neuroscience
• Processes