Vandetanib, VEGFR2 tyrosine kinase inhibitor (ab142099)
Key features and details
- Orally available, potent VEGFR2 tyrosine kinase inhibitor
- CAS Number: 443913-73-3
- Purity: > 98%
- Soluble in DMSO to 50 mM and in ethanol to 10 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Vandetanib, VEGFR2 tyrosine kinase inhibitor -
製品の詳細
Orally available, potent VEGFR2 tyrosine kinase inhibitor -
別名
- 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-yl)methoxy]quinazoline
- Caprelsa®
- CH 331
see all -
生理活性の詳細
Orally available, potent VEGFR2 tyrosine kinase inhibitor (KDR IC50 = 40 nM). Also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC50 = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC50 = 500 nM) but shows selectivity against a panel of other tyrosine and serine-threonine kinases. Displays anti-angiogenesis activity.
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精製度
> 98% -
CAS 番号
443913-73-3 -
構造式
製品の特性
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体系名
N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy] quinazolin-4-amine -
分子量
475.35 -
分子式
C22H24BrFN4O2 -
PubChem 登録番号
3081361 -
保存方法
Shipped at Room Temperature. Store at -20°C. Store under desiccating conditions. -
溶解性
Soluble in DMSO to 50 mM and in ethanol to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC -
由来
Synthetic
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研究分野
画像
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Chemical Structure - Vandetanib, VEGFR2 tyrosine kinase inhibitor (ab142099)2D chemical structure image of ab142099, Vandetanib, VEGFR2 tyrosine kinase inhibitor
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab142099 は論文での使用が確認できていません。