UC2288, p21 inhibitor (ab146969)
Key features and details
- Novel, selective, cell permeable p21 inhibitor
- CAS Number: 1394011-91-6
- Purity: > 98%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
UC2288, p21 inhibitor -
製品の詳細
Novel, selective, cell permeable p21 inhibitor -
別名
- p21/Cip1/CKI/Waf1 Inhibitor
- t-CTTU
- trans-1-(4-Chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)-urea
- UC-2288
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生理活性の詳細
Cell-permeable, phenylcyclohexyl-urea based compound that selectively downregulates the expression of p21, independent of p53 expression, at either transcription or post-transcriptional level. Attenuates p21 protein levels with minimal effect on p21 protein stability. Has no significant effect on the activities of Raf kinases, VEGFR2 kinase, or the phosphorylation state of ERK. Effectively inhibits the growth of multiple cancer cell lines (GI50 = ~ 10 µM against NCI60 cell lines).
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精製度
> 98% -
CAS 番号
1394011-91-6 -
構造式
製品の特性
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体系名
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-((1r,4r)-4-(5-(trifluoromethyl)pyridin-2-yloxy)cyclohexyl)urea -
分子量
481.82 -
分子式
C20H18ClF6N3O2 -
PubChem 登録番号
60196635 -
保存方法
Shipped at Room Temperature. Store at +4°C. Store In the Dark. -
溶解性
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C1CC(CCC1NC(=O)NC2=CC(=C(C=C2)Cl)C(F)(F)F)OC3=NC=C(C=C3)C(F)(F)F -
由来
Synthetic
画像
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Chemical Structure - UC2288, p21 inhibitor (ab146969)2D chemical structure image of ab146969, UC2288, p21 inhibitor
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (4)
ab146969 は 4 報の論文で使用されています。
- Lu J et al. Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation. Invest Ophthalmol Vis Sci 63:18 (2022). PubMed: 35472217
- Huang S et al. Obg-like ATPase 1 (OLA1) overexpression predicts poor prognosis and promotes tumor progression by regulating P21/CDK2 in hepatocellular carcinoma. Aging (Albany NY) 12:3025-3041 (2020). PubMed: 32045367
- Pisonero-Vaquero S et al. TFEB Modulates p21/WAF1/CIP1 during the DNA Damage Response. Cells 9:N/A (2020). PubMed: 32397616
- Tay VSY et al. Increased double strand breaks in diabetic ß-cells with a p21 response that limits apoptosis. Sci Rep 9:19341 (2019). PubMed: 31852915