Trichostatin A, histone deacetylase inhibitor (ab120850)
Key features and details
- Potent, selective histone deacetylase inhibitor
- CAS Number: 58880-19-6
- Purity: > 98%
- Soluble in ethanol to 10 mM and in DMSO to 50 mM
- Form / State: Solid
- Source: Streptomyces sp.
製品の概要
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製品名
Trichostatin A, histone deacetylase inhibitor -
製品の詳細
Potent, selective histone deacetylase inhibitor -
生理活性の詳細
Potent, selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces cell proliferation, differentiation and apoptosis in vitro. Anticancer and antifungal agent. Active in vivo and in vitro.
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精製度
> 98% -
CAS 番号
58880-19-6 -
構造式
製品の特性
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体系名
(2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide -
分子量
302.37 -
分子式
C17H22N2O3 -
PubChem 登録番号
444732 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in ethanol to 10 mM and in DMSO to 50 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C -
由来
Streptomyces sp.
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研究分野
画像
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Chemical Structure - Trichostatin A, histone deacetylase inhibitor (ab120850)2D chemical structure image of ab120850, Trichostatin A, histone deacetylase inhibitor
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Functional Studies - Trichostatin A, histone deacetylase inhibitor (ab120850)Trichostatin A inhibits histone deacetylases in NIH/3T3 cells.Cells from logarithmic were incubated overnight with different concentrations of Trichostatin A (ab120850). Cell proteins were resolved by SDS-PAGE and probed with anti-acetylated histone antibodies.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (3)
ab120850 は 3 報の論文で使用されています。
- Hu JX et al. Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury. Cell Death Dis 13:466 (2022). PubMed: 35585040
- Wang Y et al. Dexmedetomidine attenuates the toxicity of ß-amyloid on neurons and astrocytes by increasing BDNF production under the regulation of HDAC2 and HDAC5. Mol Med Rep 19:533-540 (2019). PubMed: 30483749
- Gehring KB et al. Involvement of phosphorylated Apis mellifera CREB in gating a honeybee's behavioral response to an external stimulus. Learn Mem 23:195-207 (2016). PubMed: 27084927