JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB120728

trans-Retinoic acid, Stem cell differentiator

trans-Retinoic acid, Stem cell differentiator

Be the first to review this product! Submit a review

|

(6 Publications)

MW 300.44 g/mol, Purity >99%. Vitamin A metabolite. Induces apoptosis, shows antimitotic and antitumor activity. Differentiates various stem cells and neural progenitor cells. 3D Growth matrix component used in kidney organoid generation; also a component of brain organoid differentiation media.
2 Images
Immunocytochemistry/ Immunofluorescence - trans-Retinoic acid, Stem cell differentiator (AB120728)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - trans-Retinoic acid, Stem cell differentiator (AB120728)

ab19857 staining Oct4 in F9 cells treated with trans-retinoic acid (ab120728), by ICC/IF. Decrease of Oct4 expression correlates with increased concentration of trans-retinoic acid, as described in literature.
The cells were incubated at 37°C for 2 days in media containing different concentrations of ab120728 (trans-retinoic acid) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab19857 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - trans-Retinoic acid, Stem cell differentiator (AB120728)
  • Chemical Structure

Lab

Chemical Structure - trans-Retinoic acid, Stem cell differentiator (AB120728)

2D chemical structure image of ab120728, trans-Retinoic acid, Stem cell differentiator

Key facts

CAS番号

302-79-4

精製度

>99%

製品の状態

Solid

form

分子量

300.44 g/mol

分子式

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>8</sub>O<sub>2</sub>

由来

Synthetic

溶解性

Soluble in DMSO to 25 mM

Soluble in ethanol to 10 mM

生物学的記述

Vitamin A metabolite. Induces apoptosis, shows antimitotic and antitumor activity. Differentiates various stem cells and neural progenitor cells. 3D Growth matrix component used in kidney organoid generation; also a component of brain organoid differentiation media.

IUPAC名

3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2E,4E,6E,8E-nonatetraenoic acid

style
left-column

組合せ製品

Primary Antibodies

AB78078

Anti-beta III Tubulin antibody [2G10] - Neuronal Marker

BOND RX™ Validated|KO Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-beta III Tubulin antibody [2G10] - Neuronal Marker (AB78078)

  • 5
  • 40
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Secondary Antibodies

AB150129

Donkey Anti-Goat IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Donkey Anti-Goat IgG H&L (Alexa Fluor® 488) (AB150129)

  • 5
  • 6
Primary Antibodies

AB281588

Anti-MAP2 antibody [RM1010] - Neuronal Marker

RabMAb|Recombinant|Lab Essentials|20ul selling size

Flow Cytometry (Intracellular) - Anti-MAP2 antibody [RM1010] - Neuronal Marker (AB281588)

  • 0
  • 0
style
left-column
style
left-column

出荷温度及び保存条件

出荷温度
Ambient - Can Ship with Ice
短期保存温度
-20°C
長期保存温度
-20°C
保管に関する情報
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

|

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

|

Toxic, refer to SDS for further information.

style
left-column
style
left-column
style
left-column

製品プロトコール

style
left-column

文献 (6)

Recent publications for all applications. Explore the full list and refine your search

PeerJ 13:e19329 PubMed40292108

2025

Three distinct classes of myenteric ganglia in mice and humans: insights from quantitative analyses.

Applications

Unspecified application

Species

Unspecified reactive species

Luyao Wu,Lei Xiang,Yingjian Chen,Handan Mao,Xinyao Meng,Jing Wang,Honglin Li,Xuyong Chen,Jiexiong Feng,Jun Xiao

Brain communications 6:fcae244 PubMed39144751

2024

Inhibition of expression in human superoxide dismutase 1-mutant amyotrophic lateral sclerosis astrocytes protects against neurotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Kornélia Szebényi,Ingrid Vargová,Veselina Petrova,Jana Turečková,George M Gibbons,Monika Řehořová,Mai Abdelgawad,Alexandra Sándor,Dana Marekova,Jessica C F Kwok,Pavla Jendelová,James W Fawcett,András Lakatos

Nature communications 14:2157 PubMed37061531

2023

Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhixin Li,Kathy Nga-Chu Lui,Sin-Ting Lau,Frank Pui-Ling Lai,Peng Li,Patrick Ho-Yu Chung,Kenneth Kak-Yuen Wong,Paul Kwong-Hing Tam,Maria-Mercedes Garica-Barcelo,Chi-Chung Hui,Pak Chung Sham,Elly Sau-Wai Ngan

Bioscience reports 39: PubMed30733278

2019

Myosin Va interacts with the exosomal protein spermine synthase.

Applications

Unspecified application

Species

Unspecified reactive species

Luciano G Dolce,Rui M P Silva-Junior,Leandro H P Assis,Andrey F Z Nascimento,Jackeline S Araujo,Ingrid P Meschede,Enilza M Espreafico,Priscila O de Giuseppe,Mário T Murakami

Acta neuropathologica communications 6:70 PubMed30064522

2018

The involvement of tau in nucleolar transcription and the stress response.

Applications

Unspecified application

Species

Unspecified reactive species

Mahmoud B Maina,Laura J Bailey,Sherin Wagih,Luca Biasetti,Saskia J Pollack,James P Quinn,Julian R Thorpe,Aidan J Doherty,Louise C Serpell

Journal of the renin-angiotensin-aldosterone syste 15:243-9 PubMed25031298

2014

Effect of all-trans retinoic acid treatment on prohibitin and renin-angiotensin-aldosterone system expression in hypoxia-induced renal tubular epithelial cell injury.

Applications

Unspecified application

Species

Unspecified reactive species

Tian-Biao Zhou,Chao Ou,Liang Rong,Gregor P C Drummen
View all publications
style
left-column
style
left-column
style
right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com