JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB141116

Tramiprosate, Binds soluble amyloid-beta

Tramiprosate, Binds soluble amyloid-beta

Be the first to review this product! Submit a review

|

(2 Publications)

MW 139.18 Da. Binds soluble amyloid-β. Antifibrillogenic activity in vitro and in vivo. Sulfated glycosaminoglycan (sGAG) mimetic. Inhibits amyloid-β induced neuronal cytotoxicity. A synthetic GABA analog. Blood-brain barrier permeable and orally active.

別名を表示する

AW061132, B230208N19Rik, BcDNA:GH07312, CAE 2, CG6706, CT20836, D Gaba2, ECA 2, ECA4, ECA5, EIEE19, EJM, EJM5, FLJ36928, FLJ92613, G-protein coupled receptor 51, GAA 5, GAB B R2, GABA, GABA A, GABA A Receptor alpha 3, GABA A Receptor alpha 6 polypeptide, GABA A receptor alpha 6, GABA A receptor subunit alpha 6, GABA alpha receptor beta-2 subunit, GABA subunit A receptor alpha 6, GABA(A) receptor, GABA(A) receptor beta 1, GABA(A) receptor beta 2, GABA(A) receptor gamma 2, GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-3, GABA(A) receptor subunit alpha-4, GABA(A) receptor subunit alpha-5, GABA(A) receptor subunit alpha-6, GABA(A) receptor subunit beta-1, GABA(A) receptor subunit beta-2, GABA(A) receptor subunit beta-3, GABA(A) receptor subunit delta, GABA(A) receptor subunit gamma-1, GABA(A) receptor subunit gamma-2, GABA(A) receptor subunit gamma-3, GABA(A) receptor subunit pi, GABA(A) receptor, alpha 1, GABA-A receptor, beta-1 polypeptide, GABA-A receptor, beta-2 polypeptide, GABA-B receptor 1, GABA-B receptor 2, GABA-B-R1, GABA-B-R2, GABAA receptor beta 3 subunit, GABAA receptor subunit beta 3, GABAB subunit 1c, GABBR1, GABBR1 3, GABR A3, GABR B3, GABR G3, GABR1_HUMAN, GABR2_HUMAN, GABRA 1, GABRA 5, GABRA 6, GABRB2, GABRG 1, GABRG 2, GABRP, GARB1, GBRA1_HUMAN, GBRA3_HUMAN, GBRA4_HUMAN, GBRA5_HUMAN, GBRA6_HUMAN, GBRB1_HUMAN, GBRB2_HUMAN, GBRB3_HUMAN, GBRD_HUMAN, GBRG1_HUMAN, GBRG2_HUMAN, GBRG3_HUMAN, GBRP_HUMAN, GC138184, GEFSP 3, GH07312, GPR 51, GPRC 3B, GPRC3A, Gaba receptor alpha 1 polypeptide, GabaA/BZ, Gamma Aminobutyric Acid A Receptor Beta 1, Gamma Aminobutyric Acid Receptor , beta-1, Gamma aminobutyric acid (GABA A) receptor subunit gamma 1, Gamma aminobutyric acid (GABA) A receptor alpha 1, Gamma aminobutyric acid (GABA) A receptor alpha 3, Gamma aminobutyric acid (GABA) A receptor alpha 4, Gamma aminobutyric acid (GABA) A receptor beta 1, Gamma aminobutyric acid (GABA) A receptor beta 3, Gamma aminobutyric acid (GABA) A receptor gamma 2, Gamma aminobutyric acid (GABA) A receptor gamma 3, Gamma aminobutyric acid (GABA) A receptor pi, Gamma aminobutyric acid (GABA) A receptor, beta 2, Gamma aminobutyric acid (GABA) B receptor 1, Gamma aminobutyric acid A receptor alpha 1, Gamma aminobutyric acid A receptor alpha 3, Gamma aminobutyric acid A receptor alpha 4, Gamma aminobutyric acid A receptor alpha 6, Gamma aminobutyric acid A receptor beta 2, Gamma aminobutyric acid A receptor gamma 2, Gamma aminobutyric acid A receptor gamma 3, Gamma aminobutyric acid A receptor pi, Gamma aminobutyric acid A receptor, gamma 1, Gamma aminobutyric acid B receptor 2, Gamma aminobutyric acid GABA A receptor alpha 5, Gamma aminobutyric acid GABA A receptor alpha 5 precursor, Gamma aminobutyric acid GABA A receptor alpha 6, Gamma aminobutyric acid GABA A receptor delta, Gamma aminobutyric acid GABA B receptor 2, Gamma aminobutyric acid receptor alpha 4 subunit, Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor, Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor, Gamma aminobutyric acid receptor gamma 2 subunit, Gamma aminobutyric acid receptor pi subunit, Gamma aminobutyric acid type A receptor alpha1 subunit, Gamma-aminobutyric acid (GABA) A receptor, subunit beta 1, Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-3, Gamma-aminobutyric acid receptor subunit alpha-4, Gamma-aminobutyric acid receptor subunit alpha-5, Gamma-aminobutyric acid receptor subunit alpha-6, Gamma-aminobutyric acid receptor subunit beta-1, Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit delta, Gamma-aminobutyric acid receptor subunit gamma-1, Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid receptor subunit gamma-3, Gamma-aminobutyric acid receptor subunit pi, Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, Gamma-aminobutyric-acid receptor subunit beta-2, Gb 2, Gb1, HG 20, HRIHFB2099, MGC116903, MGC116904, MGC126386, MGC126387, MGC33793, MGC45284, MGC9051, Metabotropic GABA B receptor subtype 2, OTTHUMP00000021776, OTTHUMP00000063797, R2 SUBUNIT, Seven transmembrane helix receptor, dJ271M21.1.1, dJ271M21.1.2

1 Images
Chemical Structure - Tramiprosate, Binds soluble amyloid-beta (AB141116)
  • Chemical Structure

Lab

Chemical Structure - Tramiprosate, Binds soluble amyloid-beta (AB141116)

2D chemical structure image of ab141116, Tramiprosate, Binds soluble amyloid-beta

Key facts

CAS番号

3687-18-1

製品の状態

Solid

form

分子量

139.18 Da

分子式

C<sub>3</sub>H<sub>9</sub>NO<sub>3</sub>S

PubChem

1646

由来

Synthetic

溶解性

Soluble in water to 100 mM

化学名

Tramiprosate

生物学的記述

Binds soluble amyloid-β. Antifibrillogenic activity in vitro and in vivo. Sulfated glycosaminoglycan (sGAG) mimetic. Inhibits amyloid-β induced neuronal cytotoxicity. A synthetic GABA analog. Blood-brain barrier permeable and orally active.

Canonical smiles

C(CN)CS(=O)(=O)O

InChi

InChI=1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)

InChiKey

SNKZJIOFVMKAOJ-UHFFFAOYSA-N

IUPAC名

3-aminopropane-1-sulfonic acid

出荷温度及び保存条件

出荷温度
Ambient - Can Ship with Ice
短期保存温度
+4°C
長期保存温度
+4°C
保管に関する情報
The product can be stored for up to 12 months

製品プロトコール

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 26: PubMed40332390

2025

Combination of Epigallocatechin-3-Gallate and Tramiprosate Prevent Accumulation of Intracellular Aβ and Dysfunctional Autophagy-Lysosomal Pathway at Earliest Stage of Transdifferentiation of Mesenchymal Stromal Cells into PSEN1 E280A Cholinergic-like Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Viviana Soto-Mercado,Miguel Mendivil-Perez,Marlene Jimenez-Del-Rio,Carlos Velez-Pardo

International journal of molecular sciences 25: PubMed38732141

2024

Combination of Tramiprosate, Curcumin, and SP600125 Reduces the Neuropathological Phenotype in Familial Alzheimer Disease PSEN1 I416T Cholinergic-like Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Nicolas Gomez-Sequeda,Marlene Jimenez-Del-Rio,Carlos Velez-Pardo
View all publications

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com