TOFA (5-(tetradecyloxy)-2-furoic acid), acetyl-CoA carboxylase inhibitor. (ab141578)
Key features and details
- Potent, reversible and competitive acetyl-CoA carboxylase inhibitor.
- CAS Number: 54857-86-2
- Purity: > 99%
- Soluble in DMSO to 25 mM and in ethanol
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
TOFA (5-(tetradecyloxy)-2-furoic acid), acetyl-CoA carboxylase inhibitor. -
製品の詳細
Potent, reversible and competitive acetyl-CoA carboxylase inhibitor. -
生理活性の詳細
Potent, reversible, competitive acetyl-CoA carboxylase (ACC) inhibitor.
Hypolipidemic agent, active in vivo. Cell-permeable. -
精製度
> 99% -
CAS 番号
54857-86-2 -
構造式
製品の特性
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体系名
5-Tetradecoxyfuran-2-carboxylic acid -
分子量
324.50 -
分子式
C19H32O4 -
PubChem 登録番号
115175 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 25 mM and in ethanol -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CCCCCCCCCCCCCCOC1=CC=C(O1)C(=O)O -
由来
Synthetic
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研究分野
画像
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Chemical Structure - TOFA (5-(tetradecyloxy)-2-furoic acid), acetyl-CoA carboxylase inhibitor. (ab141578)2D chemical structure image of ab141578, TOFA (5-(tetradecyloxy)-2-furoic acid), acetyl-CoA carboxylase inhibitor.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (6)
ab141578 は 6 報の論文で使用されています。
- Liu S et al. Acetyl-CoA carboxylase 1 depletion suppresses de novo fatty acid synthesis and mitochondrial β-oxidation in castration-resistant prostate cancer cells. J Biol Chem 299:102720 (2023). PubMed: 36410440
- Veprik A et al. Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion. Commun Biol 5:238 (2022). PubMed: 35304577
- Miralpeix C et al. Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status. Br J Pharmacol 178:1507-1523 (2021). PubMed: 33444462
- Casas M et al. Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking. J Cell Biol 219:N/A (2020). PubMed: 32931550
- Palomo-Guerrero M et al. Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth. Elife 8:N/A (2019). PubMed: 31868590
- Lee JH et al. RNF20 Suppresses Tumorigenesis by Inhibiting SREBP1c-PTTG1 Axis in Kidney Cancer. Mol Cell Biol N/A:N/A (2017). PubMed: 28827316
