Tie2 kinase inhibitor, ATP-binding site-targeting Tie2 kinase inhibitor. Cell-permeable. (ab141270)
Key features and details
- Potent, reversible and selective ATP-binding site-targeting Tie2 kinase inhibitor. Cell-permeable.
- CAS Number: 948557-43-5
- Purity: > 98%
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Tie2 kinase inhibitor, ATP-binding site-targeting Tie2 kinase inhibitor. Cell-permeable. -
製品の詳細
Potent, reversible and selective ATP-binding site-targeting Tie2 kinase inhibitor. Cell-permeable. -
生理活性の詳細
Potent, reversible and selective ATP-binding site-targeting Tie2 kinase inhibitor (IC50 = 250 nM). Anti- angiogenesis agent. Active in vivo and in vivo. Cell-permeable.
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精製度
> 98% -
CAS 番号
948557-43-5 -
構造式
製品の特性
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体系名
4-[4-(6-Methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine -
分子量
439.53 -
分子式
C26H21N3O2S -
PubChem 登録番号
23625762 -
保存方法
Store at +4°C. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 50 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CS(=O)c1ccc(cc1)c2nc(c(n2)c3cc4ccc(OC)cc4cc3)c5ccncc5 -
由来
Synthetic
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研究分野
画像
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Chemical Structure - Tie2 kinase inhibitor, ATP-binding site-targeting Tie2 kinase inhibitor. Cell-permeable. (ab141270)2D chemical structure image of ab141270, Tie2 kinase inhibitor, ATP-binding site-targeting Tie2 kinase inhibitor. Cell-permeable.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (2)
ab141270 は 2 報の論文で使用されています。
- Karabid NM et al. Angpt2/Tie2 autostimulatory loop controls tumorigenesis. EMBO Mol Med 14:e14364 (2022). PubMed: 35266635
- Besnier M et al. miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia. Mol Ther Nucleic Acids 17:49-62 (2019). PubMed: 31220779