Thiorphan, Neprilysin/neutral endopeptidase inhibitor
Thiorphan, Neprilysin/neutral endopeptidase inhibitor
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(1 Publication)
MW 253.32 Da, Purity >98%. Neprilysin / neutral endopeptidase inhibitor. Shows antidiarrhoeal and neuroprotective effects. Active in vivo.
別名を表示する
ACE 1, ACE T, ACE_HUMAN, Angiotensin I converting enzyme, Angiotensin I converting enzyme 1, Angiotensin I converting enzyme peptidyl dipeptidase A 1, Angiotensin converting enzyme somatic isoform, Angiotensin converting enzyme testis specific isoform, Angiotensin-converting enzyme, Atriopeptidase, CALLA, CD 143, CD10, CD10 antigen, CD143 antigen, Carboxycathepsin, Common acute lymphocytic leukemia antigen, DCP 1, DKFZp686O16152, Dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, EC 3.4.24.11, ECE, ECE1_HUMAN, EPN, Endothelin-converting enzyme 1, Enkephalinase, Kininase II, MGC126681, MGC126707, MGC26566, MME, MVCD3, Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase), Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), Membrane metallo endopeptidase variant 1, Membrane metallo endopeptidase variant 2, Membrane metalloendopeptidase, Membrane metalloendopeptidase neutral endopeptidase enkephalinase, Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10, NEP_HUMAN, NF-E2-related factor 2, NF2L2_HUMAN, NRF2, Neprilysin, Neutral endopeptidase, Neutral endopeptidase 24.11, Neutral endopeptidase, membrane-associated, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Peptidase P, Peptidyl dipeptidase A, SFE, Skin fibroblast elastase, Testicular ECA, angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript, erythroid derived 2, like 2, neprilysin-390, neprilysin-411, nuclear factor erythroid 2 like 2, soluble form
- Chemical Structure
Lab
Chemical Structure - Thiorphan, Neprilysin/neutral endopeptidase inhibitor (AB141169)
2D chemical structure image of ab141169, Thiorphan, Neprilysin/neutral endopeptidase inhibitor
出荷温度及び保存条件
出荷温度
短期保存温度
長期保存温度
保管に関する情報
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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
補足情報
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CD10 acts to modulate peptide signaling by degrading bioactive peptides including enkephalins natriuretic peptides and bradykinin. It does not function as part of a complex but participates individually in the regulation and termination of signaling events at the cellular surface. This action ensures the precise control over processes like inflammation blood pressure regulation and pain sensation by inhibiting excessive peptide activity through its enzymatic action.
Pathways
CD10 plays an important role in the renin-angiotensin system and the natriuretic peptide system. In these pathways CD10 interacts with angiotensin converting enzyme 1 often regulating blood pressure and fluid balance. In addition CD10's ability to degrade peptides contributes to the maintenance of endocrine and neuroendocrine homeostasis impacting cellular communication and signaling within these pathways.
文献 (1)
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Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8:e2101848 PubMed34363355
2021
Applications
Unspecified application
Species
Unspecified reactive species
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