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AB141169

Thiorphan, Neprilysin/neutral endopeptidase inhibitor

Thiorphan, Neprilysin/neutral endopeptidase inhibitor

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(1 Publication)

MW 253.32 Da, Purity >98%. Neprilysin / neutral endopeptidase inhibitor. Shows antidiarrhoeal and neuroprotective effects. Active in vivo.

別名を表示する

ACE 1, ACE T, ACE_HUMAN, Angiotensin I converting enzyme, Angiotensin I converting enzyme 1, Angiotensin I converting enzyme peptidyl dipeptidase A 1, Angiotensin converting enzyme somatic isoform, Angiotensin converting enzyme testis specific isoform, Angiotensin-converting enzyme, Atriopeptidase, CALLA, CD 143, CD10, CD10 antigen, CD143 antigen, Carboxycathepsin, Common acute lymphocytic leukemia antigen, DCP 1, DKFZp686O16152, Dipeptidyl carboxypeptidase 1, Dipeptidyl carboxypeptidase I, EC 3.4.24.11, ECE, ECE1_HUMAN, EPN, Endothelin-converting enzyme 1, Enkephalinase, Kininase II, MGC126681, MGC126707, MGC26566, MME, MVCD3, Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase), Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10), Membrane metallo endopeptidase variant 1, Membrane metallo endopeptidase variant 2, Membrane metalloendopeptidase, Membrane metalloendopeptidase neutral endopeptidase enkephalinase, Membrane metalloendopeptidase neutral endopeptidase enkephalinase CALLA CD10, NEP_HUMAN, NF-E2-related factor 2, NF2L2_HUMAN, NRF2, Neprilysin, Neutral endopeptidase, Neutral endopeptidase 24.11, Neutral endopeptidase, membrane-associated, Nfe2l2, Nuclear factor, Nuclear factor (erythroid derived 2) like 2, Nuclear factor erythroid 2-related factor 2, Nuclear factor erythroid derived 2 like 2, Peptidase P, Peptidyl dipeptidase A, SFE, Skin fibroblast elastase, Testicular ECA, angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript, erythroid derived 2, like 2, neprilysin-390, neprilysin-411, nuclear factor erythroid 2 like 2, soluble form

1 Images
Chemical Structure - Thiorphan, Neprilysin/neutral endopeptidase inhibitor (AB141169)
  • Chemical Structure

Lab

Chemical Structure - Thiorphan, Neprilysin/neutral endopeptidase inhibitor (AB141169)

2D chemical structure image of ab141169, Thiorphan, Neprilysin/neutral endopeptidase inhibitor

Key facts

CAS番号

76721-89-6

精製度

>98%

製品の状態

Solid

form

分子量

253.32 Da

分子式

C<sub>1</sub><sub>2</sub>H<sub>1</sub><sub>5</sub>NO<sub>3</sub>S

PubChem

3132

由来

Synthetic

溶解性

Soluble in DMSO to 100 mM

Soluble in ethanol to 100mM

化学名

Thiorphan

生物学的記述

Neprilysin / neutral endopeptidase inhibitor. Shows antidiarrhoeal and neuroprotective effects. Active in vivo.

Canonical smiles

C1=CC=C(C=C1)CC(CS)C(=O)NCC(=O)O

Isomeric smiles

C1=CC=C(C=C1)CC(CS)C(=O)NCC(=O)O

InChi

InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)

InChiKey

LJJKNPQAGWVLDQ-UHFFFAOYSA-N

IUPAC名

2-[(2-benzyl-3-sulfanylpropanoyl)amino]acetic acid

出荷温度及び保存条件

出荷温度
Ambient - Can Ship with Ice
短期保存温度
-20°C
長期保存温度
-20°C
保管に関する情報
Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD10 also known as neprilysin or neutral endopeptidase is a zinc-dependent metalloprotease with a molecular mass of approximately 100 kDa. It is predominantly expressed in various tissues such as kidney lung intestine and liver. Besides CD10 is found on the surface of certain types of immune cells like lymphocytes and neutrophils. As an enzyme it plays a role in the proteolytic cleavage of peptides by releasing their terminal amino acids except those blocked by proline.
Biological function summary

CD10 acts to modulate peptide signaling by degrading bioactive peptides including enkephalins natriuretic peptides and bradykinin. It does not function as part of a complex but participates individually in the regulation and termination of signaling events at the cellular surface. This action ensures the precise control over processes like inflammation blood pressure regulation and pain sensation by inhibiting excessive peptide activity through its enzymatic action.

Pathways

CD10 plays an important role in the renin-angiotensin system and the natriuretic peptide system. In these pathways CD10 interacts with angiotensin converting enzyme 1 often regulating blood pressure and fluid balance. In addition CD10's ability to degrade peptides contributes to the maintenance of endocrine and neuroendocrine homeostasis impacting cellular communication and signaling within these pathways.

The malfunction or altered expression of CD10 can lead to hypertension and heart failure. These disorders relate to its role in regulating the renin-angiotensin and natriuretic peptide systems. Additionally a relationship exists between CD10 and Nrf2 in cellular stress response modulation linking to oxidative stress conditions. Through these associations CD10 remains a potential therapeutic target for disease intervention strategies involving cardiovascular and neurodegenerative diseases.

製品プロトコール

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8:e2101848 PubMed34363355

2021

A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.

Applications

Unspecified application

Species

Unspecified reactive species

Shubin Yu,Yiwen Lu,An Su,Jianing Chen,Jiang Li,Boxuan Zhou,Xinwei Liu,Qidong Xia,Yihong Li,Jiaqian Li,Min Huang,Yingying Ye,Qiyi Zhao,Sushi Jiang,Xiaoqing Yan,Xiaojuan Wang,Can Di,Jiayao Pan,Shicheng Su
View all publications

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