AB120751

Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt

Name: Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt (ab120751)
Brand: Abcam Limited
SKU: AB120751
Price: 12000 JPY
Availability: InStock

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(23 Publications)

MW 318.9 Da, Purity >97%. Fluorescent cell-permeable amyloid binding benzothiazole salt. Dye used to visualise stacked β sheets in vitro and in vivo. Binding induces a shift in excitation maximum (385 nm to 450 nm) and emission maximum (445 nm to 482 nm). Highly soluble in water. Limited ability to cross the blood-brain barrier.

1 Images

Chemical Structure - Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt (AB120751)

Chemical Structure

Lab

Chemical Structure - Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt (AB120751)

2D chemical structure image of ab120751, Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt

Key facts

CAS番号

2390-54-7

精製度

>97%

製品の状態

Solid

form

分子量

318.9 Da

分子式

C17H19ClN2S

PubChem

16953

由来

Synthetic

溶解性

Soluble in water to 25mM

Soluble in DMSO to 100 mM

化学名

Thioflavin T

生物学的記述

Fluorescent cell-permeable amyloid binding benzothiazole salt. Dye used to visualise stacked β sheets in vitro and in vivo. Binding induces a shift in excitation maximum (385 nm to 450 nm) and emission maximum (445 nm to 482 nm). Highly soluble in water. Limited ability to cross the blood-brain barrier.

Canonical smiles

CC1=CC2=C(C=C1)[N+](=C(S2)C3=CC=C(C=C3)N(C)C)C.[Cl-]

InChi

InChI=1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1

InChiKey

JADVWWSKYZXRGX-UHFFFAOYSA-M

IUPAC名

4-(3,6-dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline;chloride

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出荷温度及び保存条件

出荷温度

Ambient - Can Ship with Ice

短期保存温度

Ambient

長期保存温度

Ambient

保管に関する情報

The product can be stored for up to 12 months

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製品プロトコール

Visit the General protocols
Visit the Troubleshooting

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文献 (23)

Recent publications for all applications. Explore the full list and refine your search

Science advances 11:eads6132 PubMed40561024

2025

External strain on the plasma membrane is relayed to the endoplasmic reticulum by membrane contact sites and alters cellular energetics.

Applications

Unspecified application

Species

Unspecified reactive species

Ziming Chen,Peilin Chen,Jiayue Li,Euphemie Landao-Bassonga,John Papadimitriou,Junjie Gao,Delin Liu,Andrew Tai,Jinjin Ma,David Lloyd,Brendan F Kennedy,Ming Hao Zheng

MedComm 6:e70156 PubMed40276647

2025

DEAD-Box Helicase 6 Blockade in Brain-Derived Aβ Oligomers From Alzheimer's Disease Patients Attenuates Neurotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxu Wang,Lu Dai,Na Wu,Donghui Wu,Xinyuan Wang,Xia Meng,Qilei Zhang,Jing Lu,Xiaoxin Yan,Jing Zhang,Baian Chen

PLoS biology 23:e3002845 PubMed39982916

2025

RIPK1 is required for ZBP1-driven necroptosis in human cells.

Applications

Unspecified application

Species

Unspecified reactive species

Oluwamuyiwa T Amusan,Shuqi Wang,Chaoran Yin,Heather S Koehler,Yixun Li,Tencho Tenev,Rebecca Wilson,Benjamin Bellenie,Ting Zhang,Jian Wang,Chang Liu,Kim Seong,Seyedeh L Poorbaghi,Joseph Yates,Yuchen Shen,Jason W Upton,Pascal Meier,Siddharth Balachandran,Hongyan Guo

Scientific reports 15:4393 PubMed39910105

2025

Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage.

Applications

Unspecified application

Species

Unspecified reactive species

Diego Alem,César X García-Laviña,Francisco Garagorry,Dardo Centurión,Joaquina Farias,Hany Pazos-Espinosa,María Noel Cuitiño-Mendiberry,Carolina Villadóniga,Susana Castro-Sowinski,Martín Fló,Federico Carrión,Brenda Iglesias,Kevin Madauss,Lucía Canclini

Life science alliance 7: PubMed38171595

2024

Pridopidine subtly ameliorates motor skills in a mouse model for vanishing white matter.

Applications

Unspecified application

Species

Unspecified reactive species

Ellen Oudejans,Diede Witkamp,Gino V Hu-A-Ng,Leoni Hoogterp,Gemma van Rooijen-van Leeuwen,Iris Kruijff,Pleun Schonewille,Zeinab Lalaoui El Mouttalibi,Imke Bartelink,Marjo S van der Knaap,Truus Em Abbink

Science advances 9:eadi7359 PubMed37967183

2023

Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates.

Applications

Unspecified application

Species

Unspecified reactive species

Rebecca S Saleeb,Craig Leighton,Ji-Eun Lee,Judi O'Shaughnessy,Kiani Jeacock,Alexandre Chappard,Robyn Cumberland,Tianxiao Zhao,Sarah R Ball,Margaret Sunde,David J Clarke,Kristin Piché,Jacob A McPhail,Ariel Louwrier,Rachel Angers,Sonia Gandhi,Patrick Downey,Tilo Kunath,Mathew H Horrocks

The Journal of clinical investigation 133: PubMed37432737

2023

Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasis.

Applications

Unspecified application

Species

Unspecified reactive species

Deepika Awasthi,Sahil Chopra,Byuri A Cho,Alexander Emmanuelli,Tito A Sandoval,Sung-Min Hwang,Chang-Suk Chae,Camilla Salvagno,Chen Tan,Liliana Vasquez-Urbina,Jose J Fernandez Rodriguez,Sara F Santagostino,Takao Iwawaki,E Alfonso Romero-Sandoval,Mariano Sanchez Crespo,Diana K Morales,Iliyan D Iliev,Tobias M Hohl,Juan R Cubillos-Ruiz

Journal of Parkinson's disease 13:841-844 PubMed37393438

2023

Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Linn Oftedal,Jodi Maple-Grødem,Ole-Bjørn Tysnes,Guido Alves,Johannes Lange

Cell reports 33:108266 PubMed33053340

2020

FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory Circuitry.

Applications

Unspecified application

Species

Unspecified reactive species

James C Sears,Kendal Broadie

International journal of molecular sciences 21: PubMed32365658

2020

Nifedipine Upregulates ATF6-α, Caspases -12, -3, and -7 Implicating Lipotoxicity-Associated Renal ER Stress.

Applications

Unspecified application

Species

Unspecified reactive species

Chiung-Chi Peng,Chang-Rong Chen,Chang-Yu Chen,Yen-Chung Lin,Kuan-Chou Chen,Robert Y Peng

View all publications

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Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt