Telmisartan, angiotensin II (AT1) antagonist (ab120831)
Key features and details
- Selective angiotensin II (AT1) antagonist
- CAS Number: 144701-48-4
- Purity: > 99%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Telmisartan, angiotensin II (AT1) antagonist -
製品の詳細
Selective angiotensin II (AT1) antagonist -
生理活性の詳細
Selective AT1 receptor antagonist (Ki = 3.7 nM) . Partial PPAR-γ agonist.
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精製度
> 99% -
CAS 番号
144701-48-4 -
構造式
製品の特性
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体系名
4'-[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid -
分子量
514.63 -
分子式
C33H30N4O2 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 10 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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由来
Synthetic
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研究分野
関連製品
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アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab120831の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
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| 特記事項 |
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Functional Studies
Use at an assay dependent concentration. |
画像
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Chemical Structure - Telmisartan, angiotensin II (AT1) antagonist (ab120831)2D chemical structure image of ab120831, Telmisartan, angiotensin II (AT1) antagonist
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Functional Studies - Telmisartan, angiotensin II (AT1) antagonist (ab120831)ab8934 staining PPARα in serum starved HepG2 cells treated with telmisartan (ab120831), by ICC/IF. Increase in PPARα expression correlates with increased concentration of telmisartan, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120831 (telmisartan) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab8934 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (1)
ab120831 は 1 報の論文で使用されています。
- Zhang X et al. Telmisartan Mitigates TNF-a-Induced Type II Collagen Reduction by Upregulating SOX-9. ACS Omega 6:11756-11761 (2021). PubMed: 34056329