TAPI-2, MMP and ADAM inhibitor (ab142219)
Key features and details
- Broad spectrum MMP and ADAM inhibitor
- CAS Number: 187034-31-7
- Purity: > 95%
Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
TAPI-2, MMP and ADAM inhibitor -
製品の詳細
Broad spectrum MMP and ADAM inhibitor -
別名
- TNF Protease Inhibitor 2
- Tumor necrosis factor alpha protease inhibitor 2
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精製度
> 95% -
特記事項
This product is manufactured by BioVision, an Abcam company and was previously called 2069 TAPI-2. 2069-1 is the same size as the 1 mg size of ab142219.
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CAS 番号
187034-31-7 -
構造式
製品の特性
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体系名
N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide
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分子量
415.28 -
分子式
C19H37N5O5 -
PubChem 登録番号
10093303 -
保存方法
Store at -20°C (desiccating conditions). -
溶解性
Soluble in water to 50 mM
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使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(C)CC(CC(=O)NO)C(=O)NC(C(=O)NC(C)C(=O)NCCN)C(C)(C)C -
由来
Synthetic
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (3)
ab142219 は 3 報の論文で使用されています。
- Zheng X et al. ADAM17 promotes glioma cell malignant phenotype. Mol Carcinog 51:150-64 (2012). PubMed: 21480393
- Blair CR et al. The type III TGF-ß receptor betaglycan transmembrane-cytoplasmic domain fragment is stable after ectodomain cleavage and is a substrate of the intramembrane protease ?-secretase. Biochim Biophys Acta 1813:332-9 (2011). PubMed: 21167215
- Arribas J et al. Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors. J Biol Chem 271:11376-82 (1996). PubMed: 8626692
