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AB142664

Tanshinone I, Cytotoxic to cancer cells, inhibits cell migration and invasion

Tanshinone I, Cytotoxic to cancer cells, inhibits cell migration and invasion

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MW 276.3 Da, Purity >95%. Cytotoxic to cancer cells, inhibits cell migration and invasion. Shows anti-inflammatory, Anticancer, immunosuppressive and anticoagulant agent. Active in vivo and in vitro.

別名を表示する

70Z-SHP, AI413597, AW045860, CE-2, CES2, CES2A1, Carboxylesterase 2, Carboxylesterase 2 (intestine, liver), Cocaine esterase, DDPAC, EC 3.1.1.1, EC 3.1.3.48, EST2_HUMAN, FLJ31424, FTDP 17, G protein beta1/gamma2 subunit interacting factor 1, HCP, HCPH, HPTP1C, Hematopoietic cell phosphatase, Hematopoietic cell protein-tyrosine phosphatase, ICE, Iintestinal carboxylesterase liver carboxylesterase 2, Intestinal carboxylesterase; liver carboxylesterase-2, MAPT, MAPTL, MGC134287, MGC138549, MGC156663, MSTD, MTBT1, MTBT2, Methylumbelliferyl acetate deacetylase 2, Microtubule associated protein tau isoform 4, Microtubule-associated protein tau, Mtapt, Neurofibrillary tangle protein, PCE-2, PHF-tau, PPND, PPP1R103, PTN6_HUMAN, PTP-1C, Paired helical filament-tau, Protein phosphatase 1, regulatory subunit 103, Protein tyrosine phosphatase non receptor type 6, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase SHP-1, Ptpn6, RNPTAU, SH-PTP1, SHP 1L, TAU_HUMAN, Tauopathy and respiratory failure, Tauopathy and respiratory failure, included, Tyrosine-protein phosphatase non-receptor type 6, hCE-2, pTau

1 Images
Chemical Structure - Tanshinone I, Cytotoxic to cancer cells, inhibits cell migration and invasion (AB142664)
  • Chemical Structure

Lab

Chemical Structure - Tanshinone I, Cytotoxic to cancer cells, inhibits cell migration and invasion (AB142664)

2D chemical structure image of ab142664, Tanshinone I, Cytotoxic to cancer cells, inhibits cell migration and invasion

Key facts

CAS番号

568-73-0

精製度

>95%

製品の状態

Solid

form

作製由来

Salvia miltiorrhiza Bunge

分子量

276.3 Da

分子式

C<sub>1</sub><sub>8</sub>H<sub>1</sub><sub>2</sub>O<sub>3</sub>

PubChem

114917

由来

Native

溶解性

Soluble in DMSO

化学名

Tanshinone I

生物学的記述

Cytotoxic to cancer cells, inhibits cell migration and invasion. Shows anti-inflammatory, Anticancer, immunosuppressive and anticoagulant agent. Active in vivo and in vitro.

Canonical smiles

CC1=C2C=CC3=C(C2=CC=C1)C(=O)C(=O)C4=C3OC=C4C

InChi

InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3

InChiKey

AIGAZQPHXLWMOJ-UHFFFAOYSA-N

IUPAC名

1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dione

出荷温度及び保存条件

出荷温度
Ambient - Can Ship with Ice
長期保存温度
+4°C
保管に関する情報
The product can be stored for up to 12 months

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Tau also known as MAPT (microtubule-associated protein tau) is a protein with a mass of approximately 80 kDa. It primarily stabilizes microtubules in neurons and is found mainly in the brain. SHP-1 also known as PTPN6 (protein tyrosine phosphatase non-receptor type 6) has a mass of about 68 kDa and functions in hematopoietic cells such as lymphocytes and monocytes. CES2 or carboxylesterase 2 weighs around 62 kDa and is expressed predominantly in the liver and digestive tract where it plays a role in drug metabolism.
Biological function summary

Tau maintains microtubule stability which is essential for neuronal transport and function. Tau does not often form complexes but can be hyperphosphorylated affecting its function. SHP-1 is a cytoplasmic tyrosine phosphatase that regulates signaling pathways in immune cells often being part of larger signaling complexes. CES2 is involved in hydrolyzing ester and amide bonds critical for the detoxification of various substances and metabolism of some prodrugs.

Pathways

Tau closely links to the MAPK signaling pathway influencing neuronal growth and differentiation. It interacts with proteins like tubulin in microtubules. SHP-1 is an important regulator in the JAK/STAT signaling pathway modulating cytokine signaling in immune responses. It interacts with upstream kinases and downstream proteins like STAT. CES2 is integral to the xenobiotic metabolism mechanism playing a part in drug detoxification involving the cytochrome P450 enzymes.

Tau is significant in neurodegenerative diseases such as Alzheimer's Disease where tau tangles disrupt neuronal function. This connection occurs alongside amyloid-beta proteins. SHP-1 relates to autoimmune diseases affecting the regulation of immune responses due to its role in lymphocyte signaling. CES2 is relevant to drug resistance in cancer as it activates prodrugs used in chemotherapy. In such cases CES2 connects with transport proteins that regulate drug efflux or uptake.

製品プロトコール

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