SR95531 (Gabazine), GABAA antagonist (ab120042)
Key features and details
- GABAA antagonist
- CAS Number: 104104-50-9
- Soluble in water to 25 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
SR95531 (Gabazine), GABAA antagonist -
製品の詳細
GABAA antagonist -
別名
- Gabazine
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生理活性の詳細
Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM.
Also available in simple stock solutions (ab144487) - add 1 ml of water to get an exact, ready-to-use concentration. -
CAS 番号
104104-50-9 -
構造式
製品の特性
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体系名
2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide -
分子量
368.23 -
分子式
C15H17N3O3.HBr -
PubChem 登録番号
107895 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 25 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
[Br-].COc1ccc(cc1)C=2C=CC(=[NH2+])N(CCCC(=O)O)N=2 -
由来
Synthetic
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研究分野
画像
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Chemical Structure - SR95531 (Gabazine), GABAA antagonist (ab120042)2D chemical structure image of ab120042, SR95531 (Gabazine), GABAA antagonist
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Cellular activation - SR95531 (Gabazine), GABAA antagonist (ab120042)Image from Maher BJ, LoTurco JJ, Plos One, 7(3), e34053. Fig 1,; doi: 10.1371/journal.pone.0034053Expression of DISC1ΔC is induced by postnatal administration of 4-OHT as seen by expression of GFP fused to DISC1ΔC in this P28 brain slice. No GFP expression is observed in vehicle treated animals (- 4-OHT). Scale bar equals 100 µm. Performed in the presence of gabazine (5 µM) and TTX (1 µM).
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Functional Studies - SR95531 (Gabazine), GABAA antagonist (ab120042)Image from Brady JD et al., Neuroscience. 2010;168(1):108-17. Fig 3.; doi: 10.1016/j.neuroscience.2010.03.009 with permission from Elsevier.A. Purkinje cell response to simulated ischemia (OGD only) in the continuous presence of the GABAA antagonist GABAzine (ab120042, 10 μM), and during subsequent block of glutamate receptors with AP5 (ab120003, 50 μM) + NBQX (ab120045, 25 μM). B. Bar charts summarize the timing and magnitude of ischemia-induced glutamate currents (for both methods of simulating ischemia) with and without GABAA receptors blocked. Iglu is the magnitude of current blocked by AP5 (ab120003, 50 μM) + NBQX (ab120045, 25 μM).
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (156)
ab120042 は 156 報の論文で使用されています。
- Kintscher M et al. A striatal circuit balances learned fear in the presence and absence of sensory cues. Elife 12:N/A (2023). PubMed: 36655978
- Jin X et al. WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release. J Clin Invest 133:N/A (2023). PubMed: 37071482
- Lin C et al. Functional imaging-guided cell selection for evolving genetically encoded fluorescent indicators. Cell Rep Methods 3:100544 (2023). PubMed: 37671014
- Chou MY et al. Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice. Commun Biol 6:267 (2023). PubMed: 36918719
- Gonzalez JC et al. Circadian regulation of dentate gyrus excitability mediated by G-protein signaling. Cell Rep 42:112039 (2023). PubMed: 36749664
