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AB120042

SR95531 (Gabazine), GABAA antagonist

SR95531 (Gabazine), GABAA antagonist

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(159 Publications)

SR95531 (Gabazine)(CAS: 104104-50-9)(ab120042) is a selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. MW 368.23.

- Proven performance: cited in over 150 publications
- Available in different sizes to fit your experimental needs

別名を表示する

AW061132, B230208N19Rik, CAE 2, ECA 2, ECA4, ECA5, EIEE19, EJM, EJM5, GAA 5, GABA, GABA A, GABA A Receptor alpha 3, GABA A Receptor alpha 6 polypeptide, GABA A receptor alpha 6, GABA A receptor subunit alpha 6, GABA alpha receptor beta-2 subunit, GABA subunit A receptor alpha 6, GABA(A) receptor, GABA(A) receptor beta 1, GABA(A) receptor beta 2, GABA(A) receptor gamma 2, GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-3, GABA(A) receptor subunit alpha-4, GABA(A) receptor subunit alpha-5, GABA(A) receptor subunit alpha-6, GABA(A) receptor subunit beta-1, GABA(A) receptor subunit beta-2, GABA(A) receptor subunit beta-3, GABA(A) receptor subunit delta, GABA(A) receptor subunit gamma-1, GABA(A) receptor subunit gamma-2, GABA(A) receptor subunit gamma-3, GABA(A) receptor subunit pi, GABA(A) receptor, alpha 1, GABA-A receptor, beta-1 polypeptide, GABA-A receptor, beta-2 polypeptide, GABAA receptor beta 3 subunit, GABAA receptor subunit beta 3, GABR A3, GABR B3, GABR G3, GABRA 1, GABRA 5, GABRA 6, GABRB2, GABRG 1, GABRG 2, GABRP, GARB1, GBRA1_HUMAN, GBRA3_HUMAN, GBRA4_HUMAN, GBRA5_HUMAN, GBRA6_HUMAN, GBRB1_HUMAN, GBRB2_HUMAN, GBRB3_HUMAN, GBRD_HUMAN, GBRG1_HUMAN, GBRG2_HUMAN, GBRG3_HUMAN, GBRP_HUMAN, GC138184, GEFSP 3, Gaba receptor alpha 1 polypeptide, GabaA/BZ, Gamma Aminobutyric Acid A Receptor Beta 1, Gamma Aminobutyric Acid Receptor , beta-1, Gamma aminobutyric acid (GABA A) receptor subunit gamma 1, Gamma aminobutyric acid (GABA) A receptor alpha 1, Gamma aminobutyric acid (GABA) A receptor alpha 3, Gamma aminobutyric acid (GABA) A receptor alpha 4, Gamma aminobutyric acid (GABA) A receptor beta 1, Gamma aminobutyric acid (GABA) A receptor beta 3, Gamma aminobutyric acid (GABA) A receptor gamma 2, Gamma aminobutyric acid (GABA) A receptor gamma 3, Gamma aminobutyric acid (GABA) A receptor pi, Gamma aminobutyric acid (GABA) A receptor, beta 2, Gamma aminobutyric acid A receptor alpha 1, Gamma aminobutyric acid A receptor alpha 3, Gamma aminobutyric acid A receptor alpha 4, Gamma aminobutyric acid A receptor alpha 6, Gamma aminobutyric acid A receptor beta 2, Gamma aminobutyric acid A receptor gamma 2, Gamma aminobutyric acid A receptor gamma 3, Gamma aminobutyric acid A receptor pi, Gamma aminobutyric acid A receptor, gamma 1, Gamma aminobutyric acid GABA A receptor alpha 5, Gamma aminobutyric acid GABA A receptor alpha 5 precursor, Gamma aminobutyric acid GABA A receptor alpha 6, Gamma aminobutyric acid GABA A receptor delta, Gamma aminobutyric acid receptor alpha 4 subunit, Gamma aminobutyric acid receptor alpha 5 subunit precursor GABA A receptor, Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor, Gamma aminobutyric acid receptor gamma 2 subunit, Gamma aminobutyric acid receptor pi subunit, Gamma aminobutyric acid type A receptor alpha1 subunit, Gamma-aminobutyric acid (GABA) A receptor, subunit beta 1, Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-3, Gamma-aminobutyric acid receptor subunit alpha-4, Gamma-aminobutyric acid receptor subunit alpha-5, Gamma-aminobutyric acid receptor subunit alpha-6, Gamma-aminobutyric acid receptor subunit beta-1, Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit delta, Gamma-aminobutyric acid receptor subunit gamma-1, Gamma-aminobutyric acid receptor subunit gamma-2, Gamma-aminobutyric acid receptor subunit gamma-3, Gamma-aminobutyric acid receptor subunit pi, Gamma-aminobutyric-acid receptor subunit beta-2, MGC116903, MGC116904, MGC126386, MGC126387, MGC33793, MGC45284, MGC9051

3 Images
Chemical Structure - SR95531 (Gabazine), GABAA antagonist (AB120042)
  • Chemical Structure

Lab

Chemical Structure - SR95531 (Gabazine), GABAA antagonist (AB120042)

2D chemical structure image of ab120042, SR95531 (Gabazine), GABAA antagonist

Functional Studies (Act) - SR95531 (Gabazine), GABAA antagonist (AB120042)
  • FuncS (Act)

Unknown

Functional Studies (Act) - SR95531 (Gabazine), GABAA antagonist (AB120042)

Expression of DISC1ΔC is induced by postnatal administration of 4-OHT as seen by expression of GFP fused to DISC1ΔC in this P28 brain slice. No GFP expression is observed in vehicle treated animals (- 4-OHT). Scale bar equals 100 μm. Performed in the presence of gabazine (5 μM) and TTX (1 μM).

Image from Maher BJ, LoTurco JJ, Plos One, 7(3), e34053. Fig 1,; doi: 10.1371/journal.pone.0034053

Functional Studies - SR95531 (Gabazine), GABAA antagonist (AB120042)
  • FuncS

PubMed

Functional Studies - SR95531 (Gabazine), GABAA antagonist (AB120042)

A. Purkinje cell response to simulated ischemia (OGD only) in the continuous presence of the GABAA antagonist GABAzine (ab120042, 10 μM), and during subsequent block of glutamate receptors with AP5 (ab120003, 50 μM) + NBQX (ab120045, 25 μM). B. Bar charts summarize the timing and magnitude of ischemia-induced glutamate currents (for both methods of simulating ischemia) with and without GABAA receptors blocked. Iglu is the magnitude of current blocked by AP5 (ab120003, 50 μM) + NBQX (ab120045, 25 μM).

Image from Brady JD et al., Neuroscience. 2010;168(1):108-17. Fig 3.; doi: 10.1016/j.neuroscience.2010.03.009 with permission from Elsevier.

Key facts

CAS番号

104104-50-9

精製度

>98%

製品の状態

Solid

form

分子量

368.23 Da

分子式

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>8</sub>BrN<sub>3</sub>O<sub>3</sub>

PubChem

107895

由来

Synthetic

化学名

1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-, monohydrobromide

生物学的記述

Selective, competitive GABAA receptor antagonist. Allosteric inhibitor of channel opening of the GABAA receptor. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Soluble in 1 ml water to give specified mM/ml concentration.

Canonical smiles

COC1=CC=C(C=C1)C2=NN(C(=N)C=C2)CCCC(=O)O.Br

InChi

InChI=1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H

InChiKey

GFZHNFOGCMEYTA-UHFFFAOYSA-N

IUPAC名

4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid;hydrobromide

製品の詳細

Check out our range of GABAA antagonist biochemicals here

出荷温度及び保存条件

出荷温度
Ambient - Can Ship with Ice
短期保存温度
+4°C
長期保存温度
+4°C
保管に関する情報
Store under desiccating conditions|The product can be stored for up to 12 months

製品プロトコール

文献 (159)

Recent publications for all applications. Explore the full list and refine your search

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 74:11 PubMed39775928

2025

Comparative analysis of adenosine 1 receptor expression and function in hippocampal and hypothalamic neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Lea Wegmann,Helmut L Haas,Olga A Sergeeva

STAR protocols 5:103255 PubMed39146190

2024

Protocol for electrophysiological measurements of circadian changes in excitability in dentate granule cells from adult mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jose Carlos Gonzalez,Haeun Lee,Linda Overstreet-Wadiche

Cell reports methods 3:100544 PubMed37671014

2023

Functional imaging-guided cell selection for evolving genetically encoded fluorescent indicators.

Applications

Unspecified application

Species

Unspecified reactive species

Chang Lin,Lihao Liu,Peng Zou

eLife 12: PubMed37490401

2023

Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling.

Applications

Unspecified application

Species

Unspecified reactive species

Kieran A Boyle,Erika Polgar,Maria Gutierrez-Mecinas,Allen C Dickie,Andrew H Cooper,Andrew M Bell,Evelline Jumolea,Adrian Casas-Benito,Masahiko Watanabe,David I Hughes,Gregory A Weir,John S Riddell,Andrew J Todd

The Journal of clinical investigation 133: PubMed37071482

2023

WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Jin,Jian Xie,Chia-Wei Yeh,Jen-Chi Chen,Chih-Jen Cheng,Cheng-Chang Lien,Chou-Long Huang

Communications biology 6:267 PubMed36918719

2023

Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ming-Yi Chou,Xuhui Cao,Kuan-Chu Hou,Meng-Han Tsai,Chih-Yu Lee,Meng-Fai Kuo,Vin-Cent Wu,Hsin-Yi Huang,Schahram Akbarian,Sheng-Kai Chang,Chung-Yi Hu,Shu-Wha Lin,Hsien-Sung Huang

Cell reports 42:112039 PubMed36749664

2023

Circadian regulation of dentate gyrus excitability mediated by G-protein signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Jose Carlos Gonzalez,Haeun Lee,Angela M Vincent,Angela L Hill,Lacy K Goode,Gwendalyn D King,Karen L Gamble,Jacques I Wadiche,Linda Overstreet-Wadiche

eLife 12: PubMed36655978

2023

A striatal circuit balances learned fear in the presence and absence of sensory cues.

Applications

Unspecified application

Species

Unspecified reactive species

Michael Kintscher,Olexiy Kochubey,Ralf Schneggenburger

eLife 11: PubMed36377439

2022

Cellular mechanisms underlying central sensitization in a mouse model of chronic muscle pain.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Ling Lin,Zhu-Sen Yang,Wai-Yi Wong,Shih-Che Lin,Shuu-Jiun Wang,Shih-Pin Chen,Jen-Kun Cheng,Hui Lu,Cheng-Chang Lien

Cell reports 41:111484 PubMed36223749

2022

Calcium-permeable AMPA receptors on AII amacrine cells mediate sustained signaling in the On-pathway of the primate retina.

Applications

Unspecified application

Species

Unspecified reactive species

Kumiko A Percival,Jacqueline Gayet,Roupen Khanjian,W Rowland Taylor,Teresa Puthussery
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