Spironolactone, Mineralocorticoid receptor antagonist (ab141289)
Key features and details
- Mineralocorticoid receptor antagonist
- CAS Number: 52-01-7
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 50 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Spironolactone, Mineralocorticoid receptor antagonist -
製品の詳細
Mineralocorticoid receptor antagonist -
別名
- SC 9420
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生理活性の詳細
Mineralocorticoid receptor antagonist (IC50 values are 24 and 77 nM at mineralocorticoid and androgen receptors respectively). Inhibits aldosterone binding to Mineralocorticoid receptor. Prevents sodium reabsorption. Active in vivo.
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精製度
> 99% -
CAS 番号
52-01-7 -
構造式
製品の特性
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体系名
(7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid-γ-lactone -
分子量
416.57 -
分子式
C24H32O4S -
PubChem 登録番号
5833 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 50 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(=O)S[C@@H]4CC1=CC(=O)CC[C@]1(C)[C@H]5CC[C@@]3(C)[C@@H](CC[C@]23CCC(=O)O2)[C@H]45 -
由来
Synthetic
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研究分野
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Retinoic & Retinoid
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Nucleotide metabolism
- Molecular processes
- Mitochondrial transcription
画像
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Chemical Structure - Spironolactone, Mineralocorticoid receptor antagonist (ab141289)2D chemical structure image of ab141289, Spironolactone, Mineralocorticoid receptor antagonist
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (3)
ab141289 は 3 報の論文で使用されています。
- Zhang B et al. The Dual Dose-Dependent Effects of Corticosterone on Hippocampal Cell Apoptosis After Traumatic Brain Injury Depend on the Activation Ratio of Mineralocorticoid Receptors to Glucocorticoid Receptors. Front Pharmacol 12:713715 (2021). PubMed: 34381366
- Ding H et al. Anti-stress effects of combined block of glucocorticoid and mineralocorticoid receptors in the paraventricular nucleus of the hypothalamus. Br J Pharmacol 178:3696-3707 (2021). PubMed: 33908038
- Zhang B et al. Corticosteroid receptor rebalancing alleviates critical illness-related corticosteroid insufficiency after traumatic brain injury by promoting paraventricular nuclear cell survival via Akt/CREB/BDNF signaling. J Neuroinflammation 17:318 (2020). PubMed: 33100225