Sivelestat, neutrophil elastase inhibitor (ab146184)
Key features and details
- Potent, selective, substrate competitive neutrophil elastase inhibitor
- CAS Number: 127373-66-4
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
Sivelestat, neutrophil elastase inhibitor -
製品の詳細
Potent, selective, substrate competitive neutrophil elastase inhibitor -
生理活性の詳細
Potent, selective, substrate competitive neutrophil elastase inhibitor (IC50 values are 19-49 nM and 5.6 μM for leukocyte and pancreas elastase respectively). Suppresses neutrophil-induced capillary permeability and leukocyte kinetics. Active in vivo. -
CAS 番号
127373-66-4 -
構造式
製品の特性
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体系名
2-[[2-[[4-(2,2-Dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid -
分子量
434.46 -
分子式
C20H22N2O7S -
PubChem 登録番号
107706 -
保存方法
Store at Room Temperature. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)O -
由来
Synthetic
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研究分野
画像
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Chemical Structure - Sivelestat, neutrophil elastase inhibitor (ab146184)2D chemical structure image of ab146184, Sivelestat, neutrophil elastase inhibitor
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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Datasheet download
参考文献 (1)
ab146184 は 1 報の論文で使用されています。
- Basso J et al. An optimized method of extracting and quantifying active Neutrophil serine proteases from human whole blood cells. PLoS One 17:e0272575 (2022). PubMed: 36044421
