AB120883

Scriptaid, HDAC inhibitor

Name: Scriptaid, HDAC inhibitor (ab120883) | Abcam
Brand: Abcam Limited
SKU: AB120883
Price: 109000 JPY
Availability: InStock

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MW 326.35 g/mol, Purity >98%. Novel HDAC inhibitor, able to cause >100-fold increase in histone acetylation. Less toxic than trichostatin A (ab120850). Induces cell cycle arrest in vitro and in vivo. .

2 Images

Immunocytochemistry/ Immunofluorescence - Scriptaid, HDAC inhibitor (AB120883)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Scriptaid, HDAC inhibitor (AB120883)

ab10812 staining histone H3 (acetyl K9) in A549 cells treated with scriptaid (ab120883), by ICC/IF. Increase in histone H3 (acetyl K9) expression correlates with increased concentration of scriptaid, as described in literature.
The cells were incubated at 37°C for 24 hour in media containing different concentrations of ab120883 (scriptaid) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab10812 (0.1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Scriptaid, HDAC inhibitor (AB120883)

Chemical Structure

Lab

Chemical Structure - Scriptaid, HDAC inhibitor (AB120883)

2D chemical structure image of ab120883, Scriptaid, HDAC inhibitor

Key facts

CAS番号

287383-59-9

精製度

>98%

分子量

326.35 g/mol

分子式

C18H18N2O4

由来

Synthetic

溶解性

Soluble in DMSO to 5 mM

生物学的記述

Novel HDAC inhibitor, able to cause >100-fold increase in histone acetylation. Less toxic than trichostatin A (ab120850). Induces cell cycle arrest in vitro and in vivo.

Canonical smiles

O=C(C1=CC=CC2=C1C3=CC=C2)N(CCCCCC(NO)=O)C3=O

IUPAC名

N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide

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出荷温度及び保存条件

出荷温度

Ambient - Can Ship with Ice

短期保存温度

-20°C

長期保存温度

-20°C

保管に関する情報

Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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製品プロトコール

Visit the General protocols
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Scriptaid, HDAC inhibitor