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AB146620

SCD1 Inhibitor (DMSO solution), SCD1(stearoyl-CoA desaturase 1) inhibitor

SCD1 Inhibitor (DMSO solution), SCD1(stearoyl-CoA desaturase 1) inhibitor

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MW 387.9 Da, Purity >99%. Potent, selective SCD1 (stearoyl-CoA desaturase 1) inhibitor (IC50 = 4.5 nM). Inhibits the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in vitro, when heptadecanoic acid and palmitic acid are used as the substrate (IC50 = 7.9 and 6.8 nM, respectively). Active in vivo. Orally bioavailable.

別名を表示する

ACOD_HUMAN, Acyl-CoA desaturase, Delta(9)-desaturase, Delta-9-Desaturase, FADS5, Fatty acid desaturase, PRO0998, Stearoyl-CoA desaturase

1 Images
Chemical Structure - SCD1 Inhibitor (DMSO solution), SCD1(stearoyl-CoA desaturase 1) inhibitor (AB146620)
  • Chemical Structure

Lab

Chemical Structure - SCD1 Inhibitor (DMSO solution), SCD1(stearoyl-CoA desaturase 1) inhibitor (AB146620)

2D chemical structure image of ab146620, SCD1 Inhibitor (DMSO solution), SCD1(stearoyl-CoA desaturase 1) inhibitor

Key facts

CAS番号

1032229-33-6

精製度

>99%

製品の状態

Liquid

form

分子量

387.9 Da

分子式

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>2</sub>ClN<sub>3</sub>O<sub>3</sub>

PubChem

24905400

由来

Synthetic

化学名

4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide

生物学的記述

Potent, selective SCD1 (stearoyl-CoA desaturase 1) inhibitor (IC50 = 4.5 nM). Inhibits the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in vitro, when heptadecanoic acid and palmitic acid are used as the substrate (IC50 = 7.9 and 6.8 nM, respectively). Active in vivo. Orally bioavailable.

Canonical smiles

CNC(=O)C1=CC(=CC=C1)NC(=O)N2CCC(CC2)OC3=CC=CC=C3Cl

InChi

InChI=1S/C20H22ClN3O3/c1-22-19(25)14-5-4-6-15(13-14)23-20(26)24-11-9-16(10-12-24)27-18-8-3-2-7-17(18)21/h2-8,13,16H,9-12H2,1H3,(H,22,25)(H,23,26)

InChiKey

DPYTYQFYDLYWHZ-UHFFFAOYSA-N

IUPAC名

4-(2-chlorophenoxy)-N-[3-(methylcarbamoyl)phenyl]piperidine-1-carboxamide

10 mM
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組合せ製品

Proteins & Peptides

AB95384

Recombinant Human Bag3 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human Bag3 protein (His tag N-Terminus) (AB95384)

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Biochemicals

AB120594

LP-12 hydrochloride, 5-HT7 agonist

Chemical Structure - LP-12 hydrochloride, 5-HT7 agonist (AB120594)

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Sample Prep & Detection Kits

AB201808

Gold Conjugation Kit (10 nm, 20 OD)

Conjugation - Gold Conjugation Kit (10 nm, 20 OD) (AB201808)

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Biochemicals

AB142567

BrdU (5-bromo-2'-deoxyuridine), Thymidine analog

Chemical Structure - BrdU (5-bromo-2'-deoxyuridine), Thymidine analog (AB142567)

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出荷温度及び保存条件

出荷温度
Ambient - Can Ship with Ice
短期保存温度
-20°C
長期保存温度
-20°C
保管に関する情報
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Stearoyl-CoA desaturase-1 (SCD1) also known as delta-9-desaturase is an enzyme integral to the synthesis of monounsaturated fats. This enzyme converts saturated fatty acyl-CoAs to monounsaturated fatty acyl-CoAs by introducing a double bond between the ninth and tenth carbon atoms a process called desaturation. SCD1 has a molecular weight of approximately 45 kDa and expresses in a variety of tissues including the liver adipose tissue and heart.
Biological function summary

SCD1 plays a significant role in fatty acid metabolism by regulating the balance of saturated and unsaturated fatty acids which impacts membrane fluidity and cellular signaling. SCD1 does not function as part of a multi-protein complex acting independently in the endoplasmic reticulum. Its expression and activity influence lipid biosynthesis and storage affecting energy homeostasis and lipid composition in cells.

Pathways

Fatty acid synthesis and oxidation pathways extensively involve SCD1. It participates mainly in the lipogenesis pathway interacting with proteins like acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS). SCD1 contributes to maintaining the ratio of oleate and palmitoleate key monounsaturated fatty acids important for cellular functions by integrating into the lipid metabolism network.

SCD1 is implicated in conditions like obesity and metabolic syndrome. Altered SCD1 activity links to insulin resistance as seen in obesity by modulating lipid profiles that influence insulin sensitivity. SCD1 associates with proteins like peroxisome proliferator-activated receptor gamma (PPARγ) which regulates adipogenesis emphasizing its role in metabolic disorders.
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製品プロトコール

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