SAG (Smo agonist), Smoothened agonist (ab142160)
Key features and details
- Cell-permeable, selective, potent Smoothened agonist
- CAS Number: 912545-86-9
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
SAG (Smo agonist), Smoothened agonist -
製品の詳細
Cell-permeable, selective, potent Smoothened agonist -
生理活性の詳細
Cell-permeable, selective, potent Smoothened agonist (EC50 = 3 nM). Binds the Smo heptahelical bundle that antagonizes cyclopamine (ab120392) action. Active in vitro and in vivo.
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精製度
> 98% -
CAS 番号
912545-86-9 -
構造式
製品の特性
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体系名
3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide -
分子量
490.06 -
分子式
C28H28ClN3OS -
PubChem 登録番号
5284330 -
保存方法
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CN[C@H]1CC[C@@H](CC1)N(Cc2ccc(cc2)c3ccncc3)C(=O)c5sc4ccccc4c5Cl -
由来
Synthetic
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研究分野
画像
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Chemical Structure - SAG (Smo agonist), Smoothened agonist (ab142160)2D chemical structure image of ab142160, SAG (Smo agonist), Smoothened agonist
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (9)
ab142160 は 9 報の論文で使用されています。
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- May EA et al. Time-resolved proteomics profiling of the ciliary Hedgehog response. J Cell Biol 220:N/A (2021). PubMed: 33856408
- Petsouki E et al. FBW7 couples structural integrity with functional output of primary cilia. Commun Biol 4:1066 (2021). PubMed: 34518642
- Yamazoe T et al. Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling. J Biol Chem 295:14723-14736 (2020). PubMed: 32820051
- Tessier S et al. NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis. Dev Biol 455:369-381 (2019). PubMed: 31301300
- Kim BH et al. Deficiency of calpain-6 inhibits primary ciliogenesis. BMB Rep 52:619-624 (2019). PubMed: 31619317
- Coulter ME et al. The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Cell Rep 24:973-986.e8 (2018). PubMed: 30044992
- Meerang M et al. Antagonizing the Hedgehog Pathway with Vismodegib Impairs Malignant Pleural Mesothelioma Growth In Vivo by Affecting Stroma. Mol Cancer Ther 15:1095-105 (2016). PubMed: 26839306
- Xing Y et al. Liver X receptor a is essential for the capillarization of liver sinusoidal endothelial cells in liver injury. Sci Rep 6:21309 (2016). PubMed: 26887957
