(R,S)-MCPG sodium salt, Group I /II metabotropic glutamate antagonist (ab120252)
Key features and details
- Group I /II metabotropic glutamate antagonist; water soluble
- CAS Number: 1303994-09-3
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
(R,S)-MCPG sodium salt, Group I /II metabotropic glutamate antagonist -
製品の詳細
Group I /II metabotropic glutamate antagonist; water soluble -
生理活性の詳細
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CAS 番号
1303994-09-3 -
構造式
製品の特性
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体系名
(R,S)-α-Methyl-4-carboxyphenylglycine sodium salt -
分子量
231.18 -
分子式
C10H10NNaO4 -
PubChem 登録番号
133698095 -
保存方法
Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM -
使用に関する注意
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CC(C1=CC=C(C=C1)C(=O)O)(C(=O)[O-])N.[Na+] -
由来
Synthetic
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研究分野
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab120252の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Functional Studies |
Use at an assay dependent concentration.
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| 特記事項 |
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Functional Studies
Use at an assay dependent concentration. |
画像
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Chemical Structure - (R,S)-MCPG sodium salt, Group I /II metabotropic glutamate antagonist (ab120252)2D chemical structure image of ab120252, (R,S)-MCPG sodium salt, Group I /II metabotropic glutamate antagonist
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Immunocytochemistry/ Immunofluorescence - (R,S)-MCPG sodium salt, Group I /II metabotropic glutamate antagonist (ab120252)ab17722 staining FMRP in SK-N-SH cells treated with (R,S)-MCPG sodium salt (ab120252), by ICC/IF. Decrease of FMRP expression correlates with increased concentration of (R,S)-MCPG sodium salt, as described in literature.
The cells were incubated at 37°C for 2h in media containing different concentrations of ab120252 ((R,S)-MCPG sodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (2)
ab120252 は 2 報の論文で使用されています。
- MacKerron C et al. A Microfluidic Platform for the Characterisation of CNS Active Compounds. Sci Rep 7:15692 (2017). PubMed: 29146949
- Goldstein BD Health effects of the gas-aerosol complex. Report to Special Committee on Health and Ecological Effects of Increased Coal Utilization. Environ Health Perspect 33:191-202 (1979). PubMed: 120252
