AB141588

QNZ, NF-kB inhibitor

Be the first to review this product! Submit a review

(8 Publications)

MW 358.4 Da, Purity >98%. Potent, selective NF-kB inhibitor (IC₅₀ = 11 nM). Inhibits LPS-induced TNFα production (IC₅₀ = 7 nM). Reduces edema in inflammation in vivo..

1 Images

Chemical Structure - QNZ, NF-kB inhibitor (AB141588)

Chemical Structure

Lab

Chemical Structure - QNZ, NF-kB inhibitor (AB141588)

2D chemical structure image of ab141588, QNZ, NF-kB inhibitor

Key facts

精製度

>98%

製品の状態

Solid

form

分子量

358.4 Da

分子式

C22H22N4O

PubChem

35026803

由来

Synthetic

溶解性

Soluble in DMSO to 50 mM

Soluble in ethanol to 25 mM

化学名

N4-[2-(4-phenoxyphenyl)ethyl]-1,2-dihydroquinazoline-4,6-diamine

生物学的記述

Potent, selective NF-kB inhibitor (IC₅₀ = 11 nM). Inhibits LPS-induced TNFα production (IC₅₀ = 7 nM). Reduces edema in inflammation in vivo.

Canonical smiles

C1NC2=C(C=C(C=C2)N)C(=N1)NCCC3=CC=C(C=C3)OC4=CC=CC=C4

InChi

InChI=1S/C22H22N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14,25H,12-13,15,23H2,(H,24,26)

InChiKey

GGBVTWRQPMDRCK-UHFFFAOYSA-N

IUPAC名

4-N-[2-(4-phenoxyphenyl)ethyl]-1,2-dihydroquinazoline-4,6-diamine

style

left-column

style

left-column

出荷温度及び保存条件

出荷温度

Ambient - Can Ship with Ice

短期保存温度

-20°C

長期保存温度

-20°C

保管に関する情報

Store under desiccating conditions|The product can be stored for up to 12 months

style

left-column

style

left-column

style

left-column

製品プロトコール

Visit the General protocols
Visit the Troubleshooting

style

left-column

文献 (8)

Recent publications for all applications. Explore the full list and refine your search

Cancer letters 587:216724 PubMed38373689

2024

CD24 negativity reprograms mitochondrial metabolism to PPARα and NF-κB-driven fatty acid β-oxidation in triple-negative breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Divya Murthy,Debasmita Dutta,Kuldeep S Attri,Tagari Samanta,Sukjin Yang,Kwang Hwa Jung,Sarah G Latario,Vasanta Putluri,Shixia Huang,Nagireddy Putluri,Jun Hyoung Park,Benny Abraham Kaipparettu

Anais da Academia Brasileira de Ciencias 95:e20220596 PubMed37132750

2023

Nuclear Factor-Kappa B-induced miRNA-518a-5p represses trophoblast cell migration and invasion by the Nuclear Factor-Kappa B pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xing Peng,Ruirui Zhang,Yumei Zhang,Chunyan Cai

Antioxidants (Basel, Switzerland) 12: PubMed36671037

2023

Mitochondria-Targeted Triphenylphosphonium-Hydroxytyrosol Prevents Lipotoxicity-Induced Endothelial Injury by Enhancing Mitochondrial Function and Redox Balance via Promoting FoxO1 and Nrf2 Nuclear Translocation and Suppressing Inflammation via Inhibiting p38/NF-кB Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xuyun Liu,Jing Gao,Yizhen Yan,Eleftheria A Georgiou,Jing Lou,Mengya Feng,Xing Zhang,Feng Gao,Jiankang Liu,Ioannis K Kostakis,Lin Zhao

Journal of innate immunity 14:629-642 PubMed35613551

2022

Regulation of TLR10 Expression and Its Role in Chemotaxis of Human Neutrophils.

Applications

Unspecified application

Species

Unspecified reactive species

Yadu Balachandran,Sarah Caldwell,Gurpreet Kaur Aulakh,Baljit Singh

Experimental physiology 105:1708-1719 PubMed32770578

2020

Inhibitory role of long non-coding RNA OIP5-AS1 in rheumatoid arthritis progression through the microRNA-448-paraoxonase 1-toll-like receptor 3-nuclear factor κB axis.

Applications

Unspecified application

Species

Unspecified reactive species

Pingying Qing,Yi Liu

Experimental and therapeutic medicine 20:2577-2584 PubMed32765751

2020

Prazosin blocks apoptosis of endothelial progenitor cells through downregulating the Akt/NF-κB signaling pathway in a rat cerebral infarction model.

Applications

Unspecified application

Species

Unspecified reactive species

Shudong Liu,Wenyan Li

Life sciences 255:117849 PubMed32473249

2020

Protective role of long noncoding RNA CRNDE in myocardial tissues from injury caused by sepsis through the microRNA-29a/SIRT1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Zhu,Aichen Sun,Taocheng Meng,Haolan Li

Journal of cellular and molecular medicine 24:7609-7624 PubMed32441055

2020

Extracellular vesicles enhance oxidative stress through P38/NF-kB pathway in ketamine-induced ulcerative cystitis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Jian Xi,Jin Jiang Zeng,Yong Lu,Shao Hua Chen,Zhi Wen Jiang,Peng Jie He,Hua Mi

View all publications

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

QNZ, NF-kB inhibitor