AB141252

Progesterone, Endogenous progesterone receptor agonist

Name: Progesterone, Endogenous progesterone receptor agonist (ab141252) | Abcam
Brand: Abcam Limited
SKU: AB141252
Price: 11000 JPY
Availability: InStock

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MW 314.5 Da, Purity >99%. Endogenous progesterone receptor agonist (EC₅₀ = 0.5 nM) C-21 steroid hormone. Elicits a variety of biological effects.

2 Images

Immunocytochemistry/ Immunofluorescence - Progesterone, Endogenous progesterone receptor agonist (AB141252)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Progesterone, Endogenous progesterone receptor agonist (AB141252)

ab16895 staining MDM2 in MCF7 cells treated with progesterone (ab141252), by ICC/IF. Decrease in MDM2 expression correlates with increased concentration of progesterone, as described in literature.
The cells were incubated at 37°C for 24 hour in media containing different concentrations of ab141252 (progesterone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab16895 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Progesterone, Endogenous progesterone receptor agonist (AB141252)

Chemical Structure

Lab

Chemical Structure - Progesterone, Endogenous progesterone receptor agonist (AB141252)

2D chemical structure image of ab141252, Progesterone, Endogenous progesterone receptor agonist

Key facts

精製度

>99%

製品の状態

Solid

form

分子量

314.5 Da

分子式

C21H30O2

PubChem

12303971

由来

Synthetic

溶解性

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

化学名

17-Acetylandrosta-4-ene-3-one

生物学的記述

Endogenous progesterone receptor agonist (EC₅₀ = 0.5 nM) C-21 steroid hormone. Elicits a variety of biological effects.

Canonical smiles

CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Isomeric smiles

CC(=O)C1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C

InChi

InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17?,18-,19-,20-,21+/m0/s1

InChiKey

RJKFOVLPORLFTN-MWXAKFKLSA-N

IUPAC名

(8S,9S,10R,13S,14S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

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出荷温度及び保存条件

出荷温度

Ambient - Can Ship with Ice

短期保存温度

+4°C

長期保存温度

+4°C

保管に関する情報

Store under desiccating conditions|The product can be stored for up to 12 months

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Toxic, refer to SDS for further information.

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製品プロトコール

Visit the General protocols
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Progesterone, Endogenous progesterone receptor agonist