PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant (ab141406)
Key features and details
- Selective NF-κB inhibitor; antioxidant
- CAS Number: 5108-96-3
- Soluble in DMSO to 100 mM and in ethanol to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant -
製品の詳細
Selective NF-κB inhibitor; antioxidant -
別名
- Ammonium pyrrolidinedithiocarbamate
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CAS 番号
5108-96-3 -
構造式
製品の特性
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体系名
1-Pyrrolidinecarbodithioic acid ammonium salt -
分子量
164.28 -
分子式
C5H9NS2.NH3 -
PubChem 登録番号
517348 -
保存方法
Store at +4°C. The product can be stored for up to 12 months. -
溶解性
Soluble in DMSO to 100 mM and in ethanol to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C1CCN(C1)C(=S)[S-].[NH4+] -
由来
Synthetic
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研究分野
- Biochemicals
- Pharmacology
- Signaling
- Signal transduction
- Nitric oxide & oxidative stress
- Antioxidants
- Biochemicals
- Research Area
- Alzheimer's Disease
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Diabetes
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
- Biochemicals
- Research Area
- Hypertension
- Signaling
- Signal transduction
- Nitric oxide signaling
- Antioxidants
画像
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Chemical Structure - PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant (ab141406)2D chemical structure image of ab141406, PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (22)
ab141406 は 22 報の論文で使用されています。
- Cho MJ et al. Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-κB inactivation. Cardiovasc Res 119:1265-1278 (2023). PubMed: 36534975
- Wang JB et al. CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages. Cancer Gene Ther N/A:N/A (2022). PubMed: 35999359
- Shayo SC et al. Dietary obesity and glycemic excursions cause a parallel increase in STEAP4 and pro-inflammatory gene expression in murine PBMCs. Diabetol Int 13:358-371 (2022). PubMed: 35463853
- Han J et al. Toll-like receptor 9 (TLR9) gene deletion-mediated fracture healing in type II diabetic osteoporosis associates with inhibition of the nuclear factor-kappa B (NF-κB) signaling pathway. Bioengineered 13:13689-13702 (2022). PubMed: 35707851
- Nam JE et al. Baicalin attenuates fibrogenic process in human renal proximal tubular cells (HK-2) exposed to diabetic milieu. Life Sci 254:117742 (2020). PubMed: 32360619