AB141406

PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant

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(23 Publications)

MW 164.3 Da. Selective NF-κB inhibitor. Inhibits translation of nitric oxide synthase mRNA to prevent induction. Metal ion chelator and antioxidant. Active in vitro.

別名を表示する

15-PGDH, 15-hydroxyprostaglandin dehydrogenase [NAD+], AHD2, AL1A1_HUMAN, ALDC, ALDH 1, ALDH 11, ALDH class 1, ALDH, liver cytosolic, ALDH-E1, ALHDII, Acetaldehyde dehydrogenase 1, Aldehyde dehydrogenase, Aldehyde dehydrogenase 1 family member A1, Aldehyde dehydrogenase 1 soluble, Aldehyde dehydrogenase 1A1, Aldehyde dehydrogenase cytosolic, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase liver cytosolic, HEL-S-53e, Hpgd, Hydroxyprostaglandin dehydrogenase 15 (NAD), MGC2318, NAD+ dependent 15 hydroxyprostaglandin dehydrogenase, OTTHUMP00000218960, OTTHUMP00000219016, OTTHUMP00000219018, PGDH1, PGDH_HUMAN, PHOAR1, PUMB 1, Prostaglandin dehydrogenase 1, RALDH 1, Retinal dehydrogenase 1, SDR36C1, Short chain dehydrogenase/reductase family 36C member 1, cytosolic, epididymis luminal protein 12, epididymis luminal protein 9, epididymis secretory sperm binding protein Li 53e

1 Images

Chemical Structure - PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant (AB141406)

Chemical Structure

Lab

Chemical Structure - PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant (AB141406)

2D chemical structure image of ab141406, PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant

Key facts

CAS番号

5108-96-3

製品の状態

Solid

form

分子量

164.3 Da

分子式

C5H12N2S2

PubChem

517348

由来

Synthetic

溶解性

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

化学名

Ammonium pyrrolidine-1-carbodithioate

生物学的記述

Selective NF-κB inhibitor. Inhibits translation of nitric oxide synthase mRNA to prevent induction. Metal ion chelator and antioxidant. Active in vitro.

Canonical smiles

C1CCN(C1)C(=S)[S-].[NH4+]

InChi

InChI=1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3

InChiKey

MDDIUTVUBYEEEM-UHFFFAOYSA-N

IUPAC名

azanium;pyrrolidine-1-carbodithioate

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出荷温度及び保存条件

出荷温度

Ambient - Can Ship with Ice

短期保存温度

+4°C

長期保存温度

+4°C

保管に関する情報

The product can be stored for up to 12 months

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ALDH1A1 also known as aldehyde dehydrogenase 1 family member A1 has a mass of approximately 54 kDa. This enzyme catalyzes the oxidation of aldehydes to carboxylic acids using NAD+ as a cofactor. ALDH1A1 plays an important role in retinoic acid biosynthesis which is important for cellular differentiation and development. This protein is expressed in a variety of tissues including the liver kidney and stem cells where it is an important marker for stem cell identification. ALDH1A1 is sometimes discussed in conjunction with 15-prostaglandin dehydrogenase (15-PGDH) due to their roles in cellular processes.

Biological function summary

ALDH1A1 participates in the detoxification of aldehydes protecting cells from oxidative stress. It is a part of the aldehyde dehydrogenase family which acts collectively to maintain cellular homeostasis. ALDH1A1 contributes to the metabolism of retinoids an essential process for stem cell differentiation and proliferation. Its activity in regulating retinoic acid levels impacts numerous biological processes supporting the conversion of vitamin A into active metabolites that affect cellular function.

Pathways

ALDH1A1 is an important player in the retinoic acid signaling pathway and the alcohol metabolism pathway. Its role in the retinoic acid signaling pathway influences gene expression involved in growth and development. ALDH1A1 works alongside retinol binding proteins and interacts with the CYP26 family of enzymes which are responsible for retinoic acid catabolism. In the alcohol metabolism pathway ALDH1A1 functions alongside alcohol dehydrogenase to process ethanol and other alcohols preventing the accumulation of toxic aldehydes.

ALDH1A1 has associations with various cancers and neurodegenerative diseases. The enzyme's role in detoxifying reactive aldehydes links it to protection against neurodegenerative disorders like Parkinson's disease where oxidative stress plays a part in neurodegeneration. In cancers ALDH1A1 functions as a cancer stem cell marker implicating it in carcinogenesis and tumor progression. The enzyme’s interaction with other proteins such as 15-PGDH further emphasizes its importance in disease contexts where inflammatory and oxidative stress pathways are involved.

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製品プロトコール

Visit the General protocols
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文献 (23)

Recent publications for all applications. Explore the full list and refine your search

Antioxidants (Basel, Switzerland) 13: PubMed39594450

2024

Artemisia Ordosica Polysaccharides Enhance Antioxidant Capacity of Peripheral Blood Lymphocytes in Poultry Through Nrf2/Keap1 and TLR4/NF-κB Signal Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyuan Xing,Yankai Zheng,Lu Chen,Yuanqing Xu,Xiao Jin,Li Hong,Sumei Yan,Binlin Shi

Cardiovascular research 119:1265-1278 PubMed36534975

2022

Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-κB inactivation.

Applications

Unspecified application

Species

Unspecified reactive species

Min Ji Cho,Dong Gwang Lee,Jeong Woong Lee,Byungtae Hwang,Sung-Jin Yoon,Seon-Jin Lee,Young-Jun Park,Seung-Ho Park,Hee Gu Lee,Yong-Hoon Kim,Chul-Ho Lee,Jangwook Lee,Nam-Kyung Lee,Tae-Su Han,Hyun-Soo Cho,Jeong Hee Moon,Ga Seul Lee,Kwang-Hee Bae,Geum-Sook Hwang,Sang-Hak Lee,Sang J Chung,Sungbo Shim,Jaehyung Cho,Goo Taeg Oh,Young-Guen Kwon,Jong-Gil Park,Jeong-Ki Min

Cancer gene therapy 30:22-37 PubMed35999359

2022

CDK5RAP3 acts as a tumour suppressor in gastric cancer through the infiltration and polarization of tumour-associated macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Jia-Bin Wang,You-Xin Gao,Yin-Hua Ye,Tong-Xing Lin,Ping Li,Jian-Xian Lin,Qi-Yue Chen,Long-Long Cao,Mi Lin,Ru-Hong Tu,Ju-Li Lin,Ze-Ning Huang,Hua-Long Zheng,Jian-Wei Xie,Chao-Hui Zheng,Chang-Ming Huang

Bioengineered 13:13689-13702 PubMed35707851

2022

Toll-like receptor 9 (TLR9) gene deletion-mediated fracture healing in type II diabetic osteoporosis associates with inhibition of the nuclear factor-kappa B (NF-κB) signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jiakai Han,Qian Zheng,Yongxia Cheng,Yong Liu,Yuxin Bai,Bin Yan,Sufen Guo,Jianbo Yu,Xinxin Li,Chong Wang

Diabetology international 13:358-371 PubMed35463853

2022

Dietary obesity and glycemic excursions cause a parallel increase in STEAP4 and pro-inflammatory gene expression in murine PBMCs.

Applications

Unspecified application

Species

Unspecified reactive species

Sigfrid Casmir Shayo,Kazuma Ogiso,Shigeru Kawade,Hiroshi Hashiguchi,Takahisa Deguchi,Yoshihiko Nishio

The American journal of pathology 190:2417-2426 PubMed32919979

2020

Transient Receptor Potential Ankyrin 1 Is Up-Regulated in Response to Lipopolysaccharide via P38/Mitogen-Activated Protein Kinase in Dental Pulp Cells and Promotes Mineralization.

Applications

Unspecified application

Species

Unspecified reactive species

Kento Tazawa,Nobuyuki Kawashima,Masashi Kuramoto,Sonoko Noda,Mayuko Fujii,Keisuke Nara,Kentaro Hashimoto,Takashi Okiji

Frontiers in cell and developmental biology 8:784 PubMed32903542

2020

Deficiency of CD147 Attenuated Non-alcoholic Steatohepatitis Progression in an NLRP3-Dependent Manner.

Applications

Unspecified application

Species

Unspecified reactive species

Tian Zhang,Hao Li,Ke Wang,Bing Xu,Zhi-Nan Chen,Huijie Bian

Folia neuropathologica 58:166-175 PubMed32729295

2020

Separate administration of ammonium pyrrolidinedithiocarbamate and phorbol myristate acetate at early and late stages decreases secondary brain injury following intracerebral haemorrhage in rats via the NF-κB pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Song,Qibing Huang,Zeli Zhang,Feng Li,Zhenkuan Xu

Life sciences 254:117742 PubMed32360619

2020

Baicalin attenuates fibrogenic process in human renal proximal tubular cells (HK-2) exposed to diabetic milieu.

Applications

Unspecified application

Species

Unspecified reactive species

Jung Eun Nam,So Yeon Jo,Chul Woo Ahn,Yu Sik Kim

Stem cells (Dayton, Ohio) 38:261-275 PubMed31721342

2019

CD10 expression identifies a subset of human perivascular progenitor cells with high proliferation and calcification potentials.

Applications

Unspecified application

Species

Unspecified reactive species

Lijun Ding,Bianca Vezzani,Nusrat Khan,Jing Su,Lu Xu,Guijun Yan,Yong Liu,Ruotian Li,Anushri Gaur,Zhenyu Diao,Yali Hu,Zhongzhou Yang,W Reef Hardy,Aaron W James,Haixiang Sun,Bruno Péault

View all publications

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PDTC (Ammonium pyrrolidinedithiocarbamate), NF-kappaB inhibitor antioxidant