Paroxetine hydrochloride (DMSO Solution) (ab147492)
Key features and details
- 5-HT uptake inhibitor
- CAS Number: 110429-35-1
- Supplied in DMSO (10 mM)
- Form / State: Liquid
- Source: Synthetic
製品の概要
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製品名
Paroxetine hydrochloride (DMSO Solution) -
製品の詳細
5-HT uptake inhibitor -
生理活性の詳細
Potent, selective 5-HT (serotonin) uptake inhibitor. Inhibits human and rat 5-HT transporters (Ki values are 0.065 and 0.05 nM, respectively). Antidepressant and anxiolytic in vivo.
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CAS 番号
110429-35-1 -
構造式
製品の特性
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体系名
(3S,4R)-3-((Benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine hydrochloride -
分子量
365.83 -
分子式
C19H20FNO3.HCl -
PubChem 登録番号
62878 -
保存方法
Shipped at Room Temperature. Store at -20°C long term. -
溶解性
Supplied in DMSO (10 mM) -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.Cl -
由来
Synthetic
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab147492 は 2 報の論文で使用されています。
- Toulme E et al. P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin. J Gen Physiol 135:333-53 (2010). PubMed: 20231374
- Mongeau R et al. 5-HT2C receptor activation prevents stress-induced enhancement of brain 5-HT turnover and extracellular levels in the mouse brain: modulation by chronic paroxetine treatment. J Neurochem 115:438-49 (2010). PubMed: 20796171